Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids

Scientific Reports
Ayaz AnwarRuqaiyyah Siddiqui

Abstract

Herein, we report green synthesized nanoparticles based on stabilization by plant gums, loaded with citrus fruits flavonoids Hesperidin (HDN) and Naringin (NRG) as novel antimicrobial agents against brain-eating amoebae and multi-drug resistant bacteria. Nanoparticles were thoroughly characterized by using zetasizer, zeta potential, atomic force microscopy, ultravoilet-visible and Fourier transform-infrared spectroscopic techniques. The size of these spherical nanoparticles was found to be in the range of 100-225 nm. The antiamoebic effects of these green synthesized Silver and Gold nanoparticles loaded with HDN and NRG were tested against Acanthamoeba castellanii and Naegleria fowleri, while antibacterial effects were evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and neuropathogenic Escherichia coli K1. Amoebicidal assays revealed that HDN loaded Silver nanoparticles stabilized by gum acacia (GA-AgNPs-HDN) quantitatively abolished amoeba viability by 100%, while NRG loaded Gold nanoparticles stabilized by gum tragacanth (GT-AuNPs-NRG) significantly reduced the viability of A. castellanii and N. fowleri at 50 µg per mL. Furthermore, these nanoparticles inhibited the encystation and excystation by more tha...Continue Reading

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Citations

Mar 4, 2020·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Noor AkbarNaveed Ahmed Khan
Aug 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Nian XiaoXing Yi
Apr 23, 2020·Antibiotics·Ayaz AnwarNaveed Ahmed Khan
Aug 21, 2020·Pharmaceutical Patent Analyst·Ruqaiyyah Siddiqui, Naveed A Khan
Sep 20, 2019·The Korean Journal of Parasitology·Chooseel BunsuwansakulVeeranoot Nissapatorn
Dec 15, 2019·Antibiotics·Abdulkader MasriRuqaiyyah Siddiqui
Sep 27, 2020·Experimental Parasitology·Geetansh SharmaUjjala Ghoshal
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahmood BaraniGeorge Z Kyzas
Feb 17, 2021·Biotechnology Advances·Pooyan MakvandiBryan Ronain Smith
Jan 4, 2021·Colloids and Surfaces. B, Biointerfaces·Annalisa ScroccarelloDario Compagnone
Apr 4, 2021·Nanomaterials·Donatella PaolinoMassimo Fresta
Jul 16, 2021·The Journal of Parasitology·Shweta WalvekarNaveed Ahmed Khan
May 15, 2021·The Journal of Eukaryotic Microbiology·Ruqaiyyah SiddiquiNaveed Ahmed Khan
Oct 27, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Peng QiDianbo Kou

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Methods Mentioned

BETA
surface plasmon resonance
AFM

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