Antimicrobial activities of stearidonic and gamma-linolenic acids from the green seaweed Enteromorpha linza against several oral pathogenic bacteria

Botanical Studies
Nam-Hee ParkIn Soon Choi

Abstract

We found that the edible green seaweed Enteromorpha linza displayed potent antimicrobial activity against Prevotella intermedia and Porphyromonas gingivalis. To elucidate the active component of E. linza, isolation procedures were performed. The main active compound was isolated by polarity fractionation, Sephadex LH-20 gel chromatography, and reverse-phase high-performance liquid chromatography (RP-HPLC). The active compounds were eluted at isocratic 95% acetonitrile by RP-HPLC and identified as unsaturated fatty acids, stearidonic acid (SA, C18:4 n-3) and gamma-linolenic acid (GLA, C18:3 n-6) by gas chromatography-mass spectrometry, (1)H nuclear magnetic resonance (NMR) spectroscopy, and (13)C NMR spectroscopy. The yields of SA and GLA from dried seaweed tissue were 6.33 × 10(-3)% and 6.47 × 10(-3)%, respectively. The minimal inhibitory concentration values of SA and GLA were 39.06 μg/mL against P. intermedia and 9.76 μg/mL against P. gingivalis, respectively. SA and GLA were also active against several other oral pathogens, including Aggregatibacter actinomycetemcomitans, Candida albicans, Fusobacterium nucleatum subsp. vincenti, and Streptococcus mutans, at micromolar concentrations. These data suggest that the E. linza ext...Continue Reading

References

Jul 1, 1986·The Journal of Infectious Diseases·H R Knapp, M A Melly
Jun 17, 2000·International Journal of Antimicrobial Agents·M E Falagas, E Siakavellas
Jan 25, 2002·Analytical Chemistry·João Aires-de-SousaJohann Gasteiger
Jul 26, 2003·Journal of Natural Products·David J NewmanKenneth M Snader
Dec 16, 2006·Current Pharmaceutical Biotechnology·Rakesh Kapoor, Yung-Sheng Huang
Sep 4, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B K Puri
Nov 3, 2010·Journal of the American Dietetic Association·Asghar Z NaqviKenneth J Mukamal

❮ Previous
Next ❯

Citations

Mar 24, 2016·Marine Drugs·María José PérezHerminia Domínguez
Nov 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiNatália Martins
Mar 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jayanta Kumar Patra, Kwang-Hyun Baek
May 27, 2015·Marine Drugs·Clara GrossoPaula B Andrade
Mar 2, 2021·Journal of Nutritional Science and Vitaminology·Akemi HosodaShunsuke Minakuchi
May 1, 2021·Marine Drugs·Eduarda M CabralMarco Garcia-Vaquero

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR
nuclear

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.