Antimicrobial activities of Tephrosia vogelii against selected pathogenic fungi and bacteria strains

Mycology
Stephano Hanolo MloziMusa Chacha

Abstract

Candida albicans and Cryptococcus neoformans are dangerous pathogens causing fungal diseases. C. albicans and C. neoformans developed resistance to fungicides such as fluconazole. Similarly, pathogenic bacteria Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Salmonella typhi have become resistant to antibiotcs such as methicillin. Thus, searching for alternative antimicrobial agents is inevitable. Tephrosia vogelii used traditionally for management of fungal and bacterial diseases is potential source of antimicrobial agents. It is in this vein that, antimicrobial activities of leaf and root extracts of T. vogelii were evaluated against C. albicans (ATCC 90028), C. neoformans (clinical isolate), S. aureus (ATCC25923), E. coli (ATCC29953), K. pneumoniae (ATCC 700603) and S. typhi (NCTC 8385). A two-fold serial dilution method using the sterilised 96 wells of polystyrene microlitre plates used to determine the minimum inhibitory concentration (MIC) of extracts. Hexane and dichloromethane extracts exhibited the lowest activity against fungi strains with MICs >10 mg/mL. Root and leaf methanolic extracts exhibited activity at MICs of 5 and 1.25 mg/mL, respectively, against both tested fungi. Dichloromethane and met...Continue Reading

References

Aug 18, 2005·Molecular Aspects of Medicine·Ameenah Gurib-Fakim
Aug 28, 2007·Journal of Ethnopharmacology·Sheila Mgole MaregesiArnold J Vlietinck
Dec 22, 2011·International Journal of Microbiology·Patrick VandeputteAlix T Coste
Jan 1, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C Arendrup
Mar 7, 2014·Pharmacognosy Reviews·Nahida Tabassum, Mariya Hamdani
Mar 31, 2015·Journal of Ethnopharmacology·Ndivhaleni A MasevheJacobus N Eloff
Oct 10, 2015·Mycoses·Diana FainiEmilio Letang
Jun 15, 2018·PLoS Neglected Tropical Diseases·Marcio L Rodrigues, Priscila C Albuquerque

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