Antimicrobial activity and molecular docking studies of a novel anthraquinone from a marine-derived fungus Aspergillus versicolor

Natural Product Research
Weiyi WangJianming Chen

Abstract

A novel anthraquinone, 2-(dimethoxymethyl)-1-hydroxyanthracene-9,10-dione (1), together with nine known compounds (2-10), were isolated from the fermentation of Aspergillus versicolor derived from deep sea sediment. Their structures were established through spectroscopic methods. Compound 1 exhibited strong inhibitory activities against MRSA ATCC 43300 and MRSA CGMCC 1.12409 (with MIC values of 3.9 and 7.8 μg/mL respectively) and moderate activities against tested strains of Vibrio (with MIC values ranging from 15.6 to 62.5 μg/mL). Compound 1 was subjected to molecular docking studies for inhibition of topoisomerase IV and AmpC β-lactamase enzymes indicating its usefulness as antimicrobial agent.

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Citations

Apr 23, 2019·Natural Product Research·Zhijun SongFuhang Song
Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Feb 6, 2020·Applied Microbiology and Biotechnology·Muhammad IbrarFariha Hasan
Jul 18, 2018·Marine Drugs·Florbela Pereira, Joao Aires-de-Sousa
May 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhi-Yong GuoPeter Proksch
Feb 10, 2021·Marine Drugs·Anton N YurchenkoEkaterina A Yurchenko
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
May 1, 2021·Microorganisms·Rodrigo Salazar Celedón, Leticia Barrientos Díaz

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Methods Mentioned

BETA
column chromatography

Software Mentioned

AutoDock
ADT

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