PMID: 9174181Jun 1, 1997Paper

Antimicrobial activity of DU-6681a, a parent compound of novel oral carbapenem DZ-2640

Antimicrobial Agents and Chemotherapy
M TanakaI Hayakawa

Abstract

The in vitro antibacterial activity of DU-6681a, a parent compound of DZ-2640, against gram-positive and -negative bacteria was compared with those of penems and cephalosporins currently available. MICs at which 90% of the isolates are inhibited (MIC90s) of the compound for clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis, including methicillin-susceptible and -resistant strains, were 0.10, 25, and 12.5 microg/ml, respectively. DU-6681a inhibited the growth of all strains of Streptococcus pyogenes and of penicillin-susceptible and -insusceptible Streptococcus pneumoniae at 0.006, 0.025, and 0.20 microg/ml, respectively, and MIC90s of the compound were 6.25 and >100 microg/ml for Enterococcus faecalis and Enterococcus faecium, respectively. MIC90s of DU-6681a were 0.20, 0.10, and 0.025 microg/ml for Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae, respectively. For Pseudomonas aeruginosa, the MIC50 and MIC90 of DU-6681a were 25 and 50 microg/ml, respectively. DU-6681a activity was not affected by different media, varied inoculum size (10(4) to 10(7) CFU), or the addition of human serum but was decreased under acidic conditions against gram-n...Continue Reading

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Citations

Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·G A PankuchP C Appelbaum
Oct 31, 2002·Pharmacology & Toxicology·Birger BrodinSven Frøkjaer
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·W J WeissR T Testa
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·W J WeissR T Testa
May 29, 1999·Antimicrobial Agents and Chemotherapy·I J HassanM R Millar
Jan 7, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bente SteffansenSven Frokjaer

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