Antimicrobial activity of DW286 against Streptococcus pneumoniae

International Journal of Antimicrobial Agents
Hee Soo ParkJin-Hwan Kwak

Abstract

DW286 is a novel broad-spectrum fluoroquinolone with excellent antipneumococcal activity. The in vitro activity of DW286 was evaluated against quinolone-susceptible and -resistant Streptococcus pneumoniae and was compared with the activities of reference compounds. Among the tested agents, DW286 showed the most potent antibacterial activity against 94 quinolone-susceptible strains [minimum inhibitory concentration (MIC) 0.008-0.03 mg/L]. Against 23 quinolone-resistant S. pneumoniae with known resistance mechanisms, DW286 also had the lowest MICs of all the tested quinolones [MIC at which 90% of isolates were inhibited (MIC(90))=0.5mg/L], followed by ciprofloxacin, sparfloxacin, moxifloxacin and gemifloxacin. The in vivo activity of DW286 against penicillin-susceptible and -resistant S. pneumoniae was more effective than that of gemifloxacin.

References

Jun 1, 1985·Cellular and Molecular Neurobiology·S B Tieman
Aug 24, 1999·Annals of Internal Medicine·M J KuehnertC A Perlino
May 11, 2002·The Journal of Antimicrobial Chemotherapy·H Lode, M Allewelt
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter C Appelbaum
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Hee-Jeong YunEung-Chil Choi
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis D Saravolatz, James Leggett
Jul 5, 2005·Expert Opinion on Investigational Drugs·A P MacGowan

❮ Previous
Next ❯

Citations

Nov 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hee-Soo ParkJin-Hwan Kwak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Peter C AppelbaumH F Khorakiwala
Antimicrobial Agents and Chemotherapy
Klaudia Kosowska-ShickPeter C Appelbaum
Antimicrobial Agents and Chemotherapy
Glenn A PankuchPeter C Appelbaum
© 2021 Meta ULC. All rights reserved