Antimicrobial activity of essential oils and carvacrol, and synergy of carvacrol and erythromycin, against clinical, erythromycin-resistant Group A Streptococci

Frontiers in Microbiology
Gloria MagiBruna Facinelli

Abstract

In the present study, we have evaluated the in vitro antibacterial activity of essential oils from Origanum vulgare, Thymus vulgaris, Lavandula angustifolia, Mentha piperita, and Melaleuca alternifolia against 32 erythromycin-resistant [Mininum Inhibitory Concentration (MIC) ≥1 μg/mL; inducible, constitutive, and efflux-mediated resistance phenotype; erm(TR), erm(B), and mef(A) genes] and cell-invasive Group A streptococci (GAS) isolated from children with pharyngotonsillitis in Italy. Over the past decades erythromycin resistance in GAS has emerged in several countries; strains combining erythromycin resistance and cell invasiveness may escape β-lactams because of intracellular location and macrolides because of resistance, resulting in difficulty of eradication and recurrent pharyngitis. Thyme and origanum essential oils demonstrated the highest antimicrobial activity with MICs ranging from 256 to 512 μg/mL. The phenolic monoterpene carvacrol [2-Methyl-5-(1-methylethyl) phenol] is a major component of the essential oils of Origanum and Thymus plants. MICs of carvacrol ranged from 64 to 256 μg/mL. In the live/dead assay several dead cells were detected as early as 1 h after incubation with carvacrol at the MIC. In single-step re...Continue Reading

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Citations

Oct 13, 2016·Frontiers in Microbiology·Bruno S Dos SantosPatrícia M G Paiva
Apr 19, 2017·Nanomaterials·Ioannis L LiakosAlexandru Mihai Grumezescu
Jun 15, 2018·Critical Reviews in Food Science and Nutrition·Jian JuWeirong Yao
May 10, 2017·Antimicrobial Agents and Chemotherapy·Zhaojun ZhengEleftherios Mylonakis
Feb 28, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Roberto VivasSona Jain
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela GruľováVincenzo De Feo
Nov 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohd AdilH P Vasantha Rupasinghe
Oct 17, 2018·Frontiers in Microbiology·Andrea Díaz-RoaPedro I Da Silva
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramaiana Soares MeloVictor Alves Carneiro
Jul 18, 2017·Frontiers in Cellular and Infection Microbiology·Hamed Haddad KashaniRezvan Moniri
Apr 28, 2020·BioMed Research International·Mantė AlmanaitytėRegina Mačianskienė
Jun 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara García-SalinasSilvia Irusta
Apr 10, 2019·Current Medicinal Chemistry·Iolanda Francolini, Antonella Piozzi
Jan 17, 2021·Scientific Reports·Niluni M WijesundaraH P Vasantha Rupasinghe
Feb 9, 2021·Critical Reviews in Food Science and Nutrition·Alberto Gonçalves EvangelistaFernando Bittencourt Luciano
Nov 1, 2020·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Nursenem KaracaFatih Demirci
Dec 23, 2020·International Journal of Molecular Sciences·Adelina LombreaCorina Danciu
May 1, 2021·Polymers·Friné Velázquez-ContrerasJosé Antonio Gabaldón

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