Antimicrobial activity of euplotin C, the sesquiterpene taxonomic marker from the marine ciliate Euplotes crassus

Antimicrobial Agents and Chemotherapy
Dianella SavoiaFernando Dini

Abstract

Strains of the marine ciliate protist Euplotes crassus produce exclusive terpenoids called euplotins that play an ecological role. Among these derivatives, euplotin C is the main of four secondary metabolites isolated from cultures of this protozoon and represents the sesquiterpene taxonomic marker from E. crassus. Because different terpenoid metabolites of plant origin showed a certain antimicrobial activity, we assessed the compound euplotin C, purified by high-pressure liquid chromatography and solubilized in two solubility enhancers, against the protozoa Leishmania major and Leishmani infantum, the fungus Candida albicans, and nine strains of gram-positive and gram-negative microorganisms. An activity of euplotin C against Leishmania promastigotes was demonstrated (50% lethal doses were 4.6 or 8.1 microg/ml depending on the agent used to solubilize the compound), while the effect was less evident on Candida and nearly absent on bacteria. A nonsignificant cytotoxicity (50% lethal dose, >200 microg/ml) against the J774 cell line was observed. A leishmanicidal activity was also shown by the living, euplotin-producing cells of E. crassus cultured together with promastigotes; this activity increased with time from 10 min to 6 h ...Continue Reading

References

Nov 14, 1997·Journal of Natural Products·H A Oketch-RabahT Theander
Mar 13, 1999·International Journal of Antimicrobial Agents·D H ChoiI K Park
Sep 10, 1999·Phytotherapy Research : PTR·A El-TahirS A Khalid
Sep 28, 1999·Letters in Applied Microbiology·S CosentinoF Palmas
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Jul 26, 2000·Planta medica·M R CamachoJ D Phillipson
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·G NagarajH Balaram
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·O KayserK Siems
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·J C DelorenziE M Saraiva
Feb 1, 2002·Natural Product Reports·M J Chan-Bacab, L M Peña-Rodríguez
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·James J BrendleKarl A Werbovetz
Apr 9, 2002·Phytochemistry·Blandine AkendengueReynald Hocquemiller
Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Jan Carlo DelorenziElvira M B Saraiva
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Suping JiangAntony J Mukkada
Aug 22, 2002·The Journal of Eukaryotic Microbiology·Dianella SavoiaLuciano Polonelli
Nov 29, 2002·The New England Journal of Medicine·Shyam SundarJonathan Berman
Mar 5, 2003·Molecular and Biochemical Parasitology·Simon L CroftMichael Duchêne
Apr 25, 2003·International Journal of Systematic and Evolutionary Microbiology·Alim Isnansetyo, Yuto Kamei
May 23, 2003·Antimicrobial Agents and Chemotherapy·Maria do Socorro S do Socorro S RosaAngela Hampshire C S Lopes
Jan 1, 1999·Angewandte Chemie·G GuellaF Pietra

❮ Previous
Next ❯

Citations

Sep 25, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Paola RamoinoCesare Usai
Jul 28, 1995·Biochimica Et Biophysica Acta·A Bernards
Jun 16, 2005·International Journal of Antimicrobial Agents·Dianella SavoiaPier-Angelo Tovo
Feb 3, 2006·Natural Product Reports·John W BluntMichèle R Prinsep
Apr 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Davide CerviaFernando Dini
May 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Freddy A Bernal, Ericsson Coy-Barrera
Aug 5, 2008·Bioorganic & Medicinal Chemistry·Dianella SavoiaSevero Salvadori
Feb 12, 2014·The Journal of Eukaryotic Microbiology·Federico BuonannoClaudio Ortenzi
Nov 20, 2008·The Journal of Eukaryotic Microbiology·Francesca TrielliFernando Dini
Jun 17, 2009·The Journal of Eukaryotic Microbiology·Davide CerviaFernando Dini
Feb 21, 2006·Experimental Parasitology·Dianella SavoiaLuciano Polonelli
Aug 30, 2008·Chemico-biological Interactions·Federico BuonannoClaudio Ortenzi
Oct 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elisabetta CatalaniDavide Cervia
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jiaen WeiZunnan Huang
Oct 10, 2021·Applied Microbiology and Biotechnology·Ana F S da CunhaSona Jain

❮ Previous
Next ❯

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