Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius.

Natural Product Research
Anna De FilippisLuisa De Martino

Abstract

The emerging concern about the increase of antibiotic resistance has encouraged research efforts to develop effective alternatives to counteract bacterial infections. Herein, we studied a new perspective to therapeutic treatment against Staphylococcus pseudintermedius, an opportunistic pathogen documented as the major cause of skin, ear, and post-operative bacterial infections in dogs and cats. Antimicrobial activity of secondary metabolites produced by selected microbial strains belonging to Trichoderma, Talaromyces, Clonostachys and Coniothyrium fungal genera has been tested against S. pseudintermedius. Several extracts, particularly those obtained from Trichoderma harzianum E45 and ET45, showed a significant antimicrobial activity towards S. pseudintermedius methicillin-resistant (MRSP) and methicillin-susceptible (MSSP) strains. Bioassay-guided fractionation of E45 and ET45 extracts allowed to isolate harzianic acid as the major compound responsible for biological activities (e.g. antimicrobial, antibiofilm formation and biofilm disaggregation).

References

Mar 24, 2004·Nature Reviews. Microbiology·Gary E HarmanMatteo Lorito
Apr 11, 2012·Veterinary Dermatology·Linda A Frank, Anette Loeffler
Apr 9, 2013·Virulence·Sarah Schmidt Grant, Deborah T Hung
Mar 11, 2017·Natural Product Research·F VinaleS L Woo
May 12, 2018·BioMed Research International·Rosalia Rodríguez-MartínezVirginia Guadalupe García-Rubio
Jun 28, 2018·The Journal of Microbiology·Donghoon Kang, Natalia V Kirienko
May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona TafuriFrancesca Ciani

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