Antimicrobial Activity of Molluscan Hemocyanins from Helix and Rapana Snails

Current Pharmaceutical Biotechnology
Pavlina DolashkaW Voelter

Abstract

For the first time the antimicrobial activities of hemocyanins from the molluscs Rapana venosa (RvH) and Helix aspersa (HaH) have been tested. From the hemolymph of the garden snail H. aspersa one structural subunit (βc-HaH ) and eight functional units (FUs, βc-HaH-a to βc-HaH-h) were isolated, and their N-terminal sequences and molecular weights, ranging between 45 and 65 kDa, determined. The antimicrobial test of the hemocyanins against different bacteria showed that only two FUs from Rapana, RvH1-b and RvH1-e, exhibit a low inhibition effect against Staphylococcus aureus. In contrast and surprisingly, the structural subunit βc-HaH of H. aspersa not only shows strong antimicrobial activities against S. aureus and the likewise Gram-positive Streptococcus epidermidis, but also against the Gram-negative bacterium Escherichia coli. We suggest that this subunit therefore has the potential to become a substitute for the commonly used antibiotics against which bacterial resistance has gradually been developed.

Citations

Aug 20, 2018·Amino Acids·Baptiste HouyvetCéline Zatylny-Gaudin
Nov 29, 2016·PLoS Neglected Tropical Diseases·Kulwadee SuwannatraiJavier Sotillo
Aug 16, 2016·Cellular and Molecular Life Sciences : CMLS·Christopher J Coates, Heinz Decker
May 13, 2017·Journal of the Science of Food and Agriculture·Fenglei LuoPengcheng Li
Mar 30, 2018·Journal of Complementary & Integrative Medicine·Giovanni Cilia, Filippo Fratini
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudio LuparelloMirella Vazzana
Mar 14, 2019·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Aleksandar DolashkiPavlina Dolashka
Sep 6, 2020·Metabolites·Nikolay G VassilevPavlinka Dolashka
Jun 17, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Jude Juventus AweyaYueling Zhang
Apr 29, 2018·Developmental and Comparative Immunology·Christopher J Coates, James Talbot
Oct 5, 2021·Frontiers in Molecular Biosciences·Khair BuxShozeb Haider

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Rumyana HristovaPavlina Dolashka-Angelova
Bulletin of Environmental Contamination and Toxicology
L K RussellR P Botts
© 2021 Meta ULC. All rights reserved