PMID: 22876608Aug 11, 2012

Antimicrobial activity of new synthesized [(oxadiazolyl)methyl]phenytoin derivatives

Acta poloniae pharmaceutica
Omar M AliAdel H Abdel-Rahman

Abstract

A number of substituted phenytoin derivatives in addition to their sugar hydrazones were newly synthesized. Furthermore, the corresponding derived 1,3,4-oxadiazole and their thioglycoside as well as their acyclic analogs were prepared. The antimicrobial activity of the prepared compounds was evaluated against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Aspergillus niger and Candida albicans. The dithiohydrazone as well as oxadiazole thiole derivatives, sugar hydrazones and acyclic nucleoside analogs were the highly active compounds.

Related Concepts

Microbicides
Filamentous fungus
Hydantol
Structure-Activity Relationship
Disk Diffusion Antimicrobial Tests
Analogs & derivatives
Aspergillus niger
Bacillus subtilis
Candida albicans
Escherichia coli

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