Antimicrobial activity of polyacetylenes from Bellis perennis and their synthetic derivatives

Planta medica
P AvatoA Tava

Abstract

The chemical investigation of the essential oils from the aerial organs of Bellis perennis L., the common daisy, showed that polyacetylenes were one of the dominant class of compounds. The major constituents, methyl deca-4,6-diynoate and deca-4,6-diynoic acid, and their structural analogues, deca-4,6-diyne, dimethyl octa-3,5-diyne-1,8-dioate and deca-4,6-diyne-1,10-dioic acid, were synthesised and their antimicrobial activity evaluated. Only deca-4,6-diynoic acid and deca-4,6-diyne-1,10-dioic acid showed antimicrobial activity, being the two compounds mainly effective against Gram-positive and Gram-negative bacteria, respectively. Structure-activity relationships of the tested polyacetylenes are discussed.

Citations

Mar 13, 2014·Pharmaceutical Biology·Fatma Pehlivan KarakasFunda Nuray Yalçın
Dec 24, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomáš Siatka, Marie Kašparová
Jan 9, 2020·Journal of Experimental Botany·Connor R Fitzpatrick, Adam C Schneider
Jun 6, 2018·BMC Complementary and Alternative Medicine·Ansar Mehmood, Ghulam Murtaza
Jun 28, 2021·Journal of Photochemistry and Photobiology. B, Biology·Vivian Maria Souza de CarvalhoCristiane D Gil

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