Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship

Phytotherapy Research : PTR
Pinarosa AvatoMarian Jurzysta

Abstract

The antimicrobial activity of saponins from Medicago sativa, M. arborea and M. arabica against a selection of medically important yeasts, Gram-positive and -negative bacteria was investigated. Structure-activity growth inhibitory effects of related prosapogenins and sapogenins are also described. Increasing antibiotic activity was observed going from the saponin extracts to the sapogenin samples, suggesting that the sugar moiety is not important for the antimicrobial efficacy. Activity was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae. The observed antimicrobial properties of M. sativa and M. arborea were related to the content of medicagenic acid, while hederagenin seems to contribute to the bioactivity of M. arabica total sapogenins.

References

Aug 1, 1986·Antimicrobial Agents and Chemotherapy·I PolacheckR Evron
Jan 1, 1965·The Journal of Organic Chemistry·R J Morris, E W Hussey
Jan 1, 1996·Advances in Experimental Medicine and Biology·A Tava, M Odoardi
Jan 1, 1996·Advances in Experimental Medicine and Biology·W Oleszek
Jan 1, 1996·Advances in Experimental Medicine and Biology·A E TimbekovaN K Abubakirov
Dec 20, 1999·Journal of Agricultural and Food Chemistry·Z BialyC Pizza
Dec 12, 2002·Phytochemistry·Anne E Osbourn
Mar 5, 2004·Journal of Agricultural and Food Chemistry·Zbigniew BialyAldo Tava

❮ Previous
Next ❯

Citations

Mar 10, 2010·Archives of Environmental Contamination and Toxicology·Vivechana DixitS Kay Obendorf
Nov 17, 2009·Applied Biochemistry and Biotechnology·Sherif M HassanChris A Bailey
Sep 10, 2013·Applied Biochemistry and Biotechnology·A RayB K Konwar
Jan 1, 2008·Animal : an International Journal of Animal Bioscience·T AcamovicN Sparks
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Catherine Kadogo KitondeMiriam Musamia Jumba
Jul 21, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Antonio RosatoRosanna Mallamaci
Nov 19, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Cromwell Mwiti Kibiti, Anthony Jide Afolayan
Nov 29, 2014·Pharmaceutical Biology·Tamyris Regina Matos LopesAna Cristina Baetas Gonçalves
Mar 4, 2017·Phytochemistry·Aldo TavaPinarosa Avato
Nov 23, 2006·Phytochemistry·Elisa BarileVirginia Lanzotti
Jun 27, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Antonio RosatoRosanna Mallamaci
May 22, 2018·Parasitology·Acidália Carine Vieira SantosMaria José Moreira Batatinha
Feb 23, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olufunmiso Olusola Olajuyigbe, Anthony Jide Afolayan
May 31, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ehsan KarimiSahida Ahmad
Jul 31, 2010·Journal of the Science of Food and Agriculture·Luciano PecettiAldo Tava
Oct 26, 2010·Pharmaceutical Biology·Kundan Singh Bora, Anupam Sharma
Jul 5, 2019·FEMS Microbiology Letters·E Ramos-MoralesC J Newbold
Feb 1, 2014·Natural Product Reports·Azra GholamiAlain Goossens
Oct 30, 2016·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Darlane W F De OliveiraDeisi A Vaz
Mar 1, 2015·Journal of Food and Drug Analysis·Yunsheng WangHanping Wu
Apr 19, 2019·Journal of Food Science and Technology·Indrajit BeraA B Mandal
Jul 25, 2019·Frontiers in Plant Science·Zhentian LeiLloyd W Sumner
Aug 7, 2019·Expert Opinion on Biological Therapy·Manica NegahdaripourYounes Ghasemi
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tommaso StefaniMaría Del Rayo Camacho-Corona
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michela MaestriniStefania Perrucci
May 31, 2019·Metabolomics : Official Journal of the Metabolomic Society·Vered TzinLloyd W Sumner
Nov 17, 2020·Frontiers in Genetics·Yee-Shan KuHon-Ming Lam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacillus Cereus Infection

Bacillus Cereus is a gram-positive bacteria that is the cause of some foodborne illnesses and leads to diarrhea and vomiting. Discover the latest research on Bacillus Cereus Infection here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.