Antimicrobial activity of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus

Biological & Pharmaceutical Bulletin
Takashi KitaharaHitoshi Sasaki

Abstract

The objective of this study was to investigate the antimicrobial activities of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus (MRSA). The antimicrobial activity of saturated fatty acids and fatty amines was determined by oxygen meters with multi-channels and disposable oxygen electrode sensors (DOX-96). Lauric acid, the most effective among the saturated fatty acids, showed antimicrobial activity at 400 microg/ml against methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA. The minimal inhibitory concentration (MIC) of fatty amines depended on each hydrophobic chain length. The MIC of myristylamine was 1.56 microg/ml; most effective of the fatty amines. In time-kill curves, lauric acid and myristylamine produced a bactericidal effect and a bacteriostatic effect at 4-fold the MIC, respectively. The antimicrobial activities of lauric acid and myristylamine were decreased by human plasma. Cytotoxicity of 3 saturated fatty acids and 3 fatty amines was examined in cultured endothelial cells. Although cytotoxicity of fatty amines was severer than that of saturated fatty acids, myristylamine showed the highest value of apparent therapeutic index among them. DOX-96 was useful for scr...Continue Reading

References

Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D L ParkerD D Blatter
Aug 1, 1985·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·K JônoE Higashide
Dec 1, 1973·The Journal of Applied Bacteriology·H Galbraith, T B Miller
Apr 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R C Spencer
Aug 25, 1999·The Journal of Antimicrobial Chemotherapy·G W Amsden
Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·W Witte
Jun 30, 2000·Journal of Theoretical Biology·L E AlcarázF H Ferretti
Jan 5, 2002·Bioorganic & Medicinal Chemistry Letters·Isao KuboKen'ichi Fujita
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Fred C TenoverBülent Bozdogan
May 1, 1948·Journal of Bacteriology·J W Foster, E S Wynne

❮ Previous
Next ❯

Citations

Nov 11, 2011·International Journal of Molecular Sciences·Garry LavertyBrendan F Gilmore
Jun 4, 2014·Marine Drugs·Christina ViegelmannRuAngelie Edrada-Ebel
Sep 14, 2012·The Quarterly Review of Biology·Joe AlcockChristopher W Kuzawa
Dec 25, 2009·The Journal of Investigative Dermatology·Teruaki NakatsujiChun-Ming Huang
Apr 24, 2009·The Journal of Investigative Dermatology·Teruaki NakatsujiChun-Ming Huang
Jun 16, 2011·Journal of Applied Microbiology·G CélizM C Audisio
Jul 28, 2015·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Agata GoszczyńskaKarol Fijałkowski
Mar 25, 2014·Journal of Amino Acids·Laetitia VidalMichel Geffard
Oct 26, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Soo KimDeokhoon Park
Mar 10, 2018·Applied Microbiology and Biotechnology·Volker F WendischFernando Pérez-García
Apr 9, 2010·Chemical Biology & Drug Design·Garry LavertyBrendan F Gilmore
Jan 24, 2019·Journal of Applied Microbiology·I SmidaZ Tamanai-Shacoori
Jan 24, 2007·The Journal of Antimicrobial Chemotherapy·André A WilliamsRichard D Gandour
Jul 12, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Zeynep KarahalilogluEmir Baki Denkbas
Apr 21, 2020·Journal of Food Protection·Janak Dhakal, Charles G Aldrich
Jul 20, 2019·Archives of Dermatological Research·Ané Orchard, Sandy F van Vuuren
Dec 23, 2016·Metabolomics : Official Journal of the Metabolomic Society·Stefan WeidtKarl E V Burgess
Apr 13, 2018·International Journal of Molecular Sciences·Bo Kyeong YoonNam-Joon Cho
Jan 1, 2020·Carbohydrate Polymers·William T HayGordon W Selling
Nov 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Daniela Radu LupoaeNicoleta Stănciuc
Oct 7, 2010·Journal of Agricultural and Food Chemistry·Andreia P OliveiraPaula Guedes de Pinho
Feb 8, 2020·ACS Applied Bio Materials·Joana M SilvaAna Rita C Duarte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.