Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus.

Annals of Clinical Microbiology and Antimicrobials
Yeliz GençYunus Bekdemir

Abstract

Staphylococcus aureus is a non-motile, gram positive, non-sporforming, facultative anaerobic microorganism. It is one of the important bacteria as a potential pathogen specifically for nosocomial infections. The sulfonamide derivative medicines are preferred to cure infection caused by S. aureus due to methicillin resistance. Antimicrobial activity of four sulfonamide derivatives have been investigated against 50 clinical isolates of S. aureus and tested by using MIC and disc diffusion methods. 50 clinical isolate which collected from specimens of patients who are given medical treatment in Ondokuz Mayis University Medical School Hospital. A control strain of S. aureus ATCC 29213 was also tested. The strongest inhibition was observed in the cases of I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid], and II [N-(2-hydroxy-5-nitro-phenyl)-4-methyl-benzensulfonamid] against S. aureus. Compound I [N-(2-hydroxy-4-nitro-phenyl)-4-methyl-benzensulfonamid] showed higher effect on 21 S. aureus MRSAisolates than oxacillin antibiotic. Introducing an electron withdrawing on the ring increased the antimicrobial activity remarkably. This study may help to suggest an alternative possible leading compound for development of new antimic...Continue Reading

References

Apr 1, 1984·European Journal of Clinical Microbiology·R P MoutonT J van der Reijden
Aug 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·M J MengelersA S Van Miert
Jan 4, 2001·International Journal of Antimicrobial Agents·D M Livermore
May 26, 2004·Bioorganic & Medicinal Chemistry·Pratibha SharmaNilesh Rane
Jun 4, 2004·American Journal of Infection Control·Stephen BentSanjay Saint
Oct 16, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Aglai ArantesOrlando Cesar Mantese
Jan 14, 2005·International Journal of Clinical Practice·U AltoparlakS Celebi
Jan 27, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Metin TemelErtap Akoğlu

❮ Previous
Next ❯

Citations

Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Samuel Ebenezer, Packianathan Thomas Muthiah
Jan 15, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Mostafa M GhorabAlbena T Dinkova-Kostova
Nov 11, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Rajendran SribalanKandasamy Ponnuvel
Dec 11, 2019·Environmental Monitoring and Assessment·Anastasiah N NgigiBoniface M Muendo
Jan 2, 2015·Acta Crystallographica. Section E, Structure Reports Online·Eswar Kumar NadendlaK Gunasekaran
Jan 1, 2018·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Neetu Agrawal, Pradeep Mishra
Mar 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lawrence Nnamdi ObasiAlfred Ezinna Ochonogor
Feb 13, 2018·Indian Journal of Microbiology·Jagdish R BadgujarJyotsna S Meshram
Apr 7, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Mustafa DurgunClaudiu T Supuran
May 4, 2021·Biophysics Reviews·Aben Ovung, Jhimli Bhattacharyya
May 27, 2021·The Journal of Physical Chemistry. a·Tarun Kumar RoyMartina Havenith
Aug 10, 2021·Journal of Gastroenterology and Hepatology·Yoshinori HanawaRyota Hokari
Oct 12, 2021·Frontiers in Nutrition·Abigail Raffner BassonFabio Cominelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.