Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae)

Journal of Ethnopharmacology
Victor KueteJ R Kuiate

Abstract

The aim of this study was to evaluate the antimicrobial activity of the methanol extracts from Ficus chlamydocarpa (FCR), Ficus cordata (FCB), mixture of the two plants (FCM), as well as that of the isolated flavonoids Alpinumisoflavone (2), Genistein (3), Laburnetin (4), Luteolin (5) (isolated from FCR), Catechin (7) and Epiafzelechin (8) (isolated from FCB). Mycobacteria, fungi, Gram-positive and Gram-negative bacterial species were tested for their susceptibility to the above samples. The microplate dilution and radiometric respiratory methods were used to determine the susceptibility testing of the samples against Mycobacterium smegmatis and Mycobacterium tuberculosis, respectively. The disc diffusion assay was used to determine the sensitivity of the samples, whilst the micro-dilution method was used for the determination of the minimal inhibition concentration (MIC) and the minimal microbicidal concentration (MMC) against fungi, Gram-positive and Gram-negative bacterial species. All the samples except compound 7 were found to be active to Mycobacterium smegmatis and the MIC ranged from 0.61 to 312.50microg/ml. Compound 4 showed the best activity against Mycobacterium tuberculosis exhibiting an MIC of 4.88microg/ml. The re...Continue Reading

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Citations

Jun 18, 2010·Antonie van Leeuwenhoek·Nazia MojibAsim K Bej
Nov 26, 2011·Natural Product Research·Frederic NanaBonaventure Tchaleu Ngadjui
May 27, 2011·BMC Complementary and Alternative Medicine·Victor KueteBerhanu M Abegaz
Jan 29, 2011·BMC Complementary and Alternative Medicine·Victor KueteBonaventure T Ngadjui
Nov 28, 2012·BMC Complementary and Alternative Medicine·Victor KueteNamrita Lall
Jul 4, 2012·BMC Complementary and Alternative Medicine·Armelle T MbavengNamrita Lall
Jul 11, 2013·BMC Complementary and Alternative Medicine·Doriane E DjeussiVictor Kuete
Jul 28, 2013·BMC Complementary and Alternative Medicine·Jaurès A K NoumedemVictor Kuete
Feb 2, 2013·BMC Complementary and Alternative Medicine·Jaurès A K NoumedemVictor Kuete
Dec 18, 2013·BMC Complementary and Alternative Medicine·Victor KueteThomas Efferth
Jul 1, 2011·Journal of Neurosciences in Rural Practice·M Obulesu, Dowlathabad Muralidhara Rao
Jan 1, 2012·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Rachael DangarembiziEliton Chivandi
Jun 30, 2014·BMC Complementary and Alternative Medicine·Rafaele C P AraujoJulio Croda
Jan 7, 2011·Redox Report : Communications in Free Radical Research·Andrea SecconTania B Creczynski-Pasa
Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Stephen T LacmataJean-Marie Pages
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Dan ZhuShiguo Chen
Jan 1, 2016·Microbiological Research·Amarendra VisamsettiDhevendaran Kandasamy
May 20, 2009·Journal of Ethnopharmacology·Victor KueteBonaventure Tchaleu Ngadjui
Mar 13, 2016·Journal of Ethnopharmacology·Kaisarun AkterJoanne F Jamie
Nov 26, 2015·BMC Research Notes·Leonard Sama FonkengJules-Roger Kuiate
Jul 4, 2015·BMC Complementary and Alternative Medicine·Sumaira SahreenTaibi Ben Hadda
Aug 2, 2011·Asian Pacific Journal of Tropical Medicine·Shahbudin SaadNurul Afifah Binti Abdul Rahim
Jun 21, 2014·Natural Product Research·Justin KamgaBonaventure T Ngadjui
Jun 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Victor KueteThomas Efferth

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