Antimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin D

Pharmaceutical Biology
S HelvaciA Güvenç

Abstract

Physalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been investigated. However, no antimicrobial activity studies on extracts and physalins of P. alkekengi have been carried out. In this study, we attempted to identify the possible antimicrobial activities of the methanol extract from aerial parts of P. alkekengi and the dichloromethane extract from calyces of the plant. The extracts were tested against five Gram-positive and five Gram-negative bacteria and five Candida species by using disk diffusion and broth microdilution methods. The extracts were fractionated to isolate physalins using chromatographic techniques, and physalin D was isolated from the extracts. The structure of the compound was elucidated on the basis of (1)H-NMR spectroscopic study, and confirmed by comparison with a reference sample and literature data. Results indicated that all the extracts and physalin D were characterized by antibacterial action, especially against Gram-positive bacteria, with ...Continue Reading

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Citations

Jun 23, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Ayda HosseinkhaniMohammad M Zarshenas
Mar 23, 2018·Complementary Medicine Research·Majid Zia-BehbahaniAbdolali Mohagheghzadeh
Dec 12, 2019·The Journal of Pharmacy and Pharmacology·Min HuangTao Shen
Sep 17, 2020·Planta medica·Sérgio Ricardo Teixeira DaltroMilena Botelho Pereira Soares
Aug 13, 2020·International Journal of Molecular Sciences·Mariarosaria Boccellino, Stefania D'Angelo
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura Gratiela VicasMariana Muresan
Jan 15, 2016·Chemistry & Biodiversity·Wen-Na Zhang, Wang-Yu Tong
Nov 25, 2021·Natural Product Reports·Gui-Yang XiaFeng Qiu

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