Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

Chemistry Central Journal
Yahia Nasser MabkhotMohammad S Mubarak

Abstract

The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics. A number of new heterocyclic compounds incorporating thiophene species have been prepared from the titled enaminone via the reaction with different nucleophiles and electrophiles. The structure elucidation of the designed compounds was derived from their spectral information. The results of antimicrobial activity of the prepared compounds revealed that derivatives 7b and 8 exhibited activity comparable to the standard drugs ampicillin and gentamicin for all tested bacteria species. Additionally, compound 3 displayed potent activity against Aspergillus fumigates, whereas compounds 5, 6, and 7a showed good activity against Syncephalastrum racemosum. We have synthesized a number of new thiophene-containing compounds. The results of antimicrobial activity of the prepared compounds revealed that changing the substituents at position-2 of thiophene ring significantly affect their biological activity. The pyridine side chain derivatives in compounds 7a, 7b and 8 showed excellent antimicrobial activity.

References

Feb 24, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sayed M Riyadh
Mar 13, 2012·International Journal of Molecular Sciences·Yahia N MabkhotSaeed A Alshahrani
Oct 4, 2013·Chemical & Pharmaceutical Bulletin·Shigeki SakamakiSumihiro Nomura
May 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yahia Nasser MabkhotWolfgang Frey
Jun 10, 2015·European Journal of Medicinal Chemistry·Thoraya A FarghalyZeinab A Muhammad
Aug 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yahia Nasser MabkhotSalim S Al-Showiman
Mar 2, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huwaida M E HassaneenYahia Nasser Mabkhot

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