PMID: 9186560Apr 1, 1997Paper

Antimicrobial activity of viridiofungins

The Journal of Antibiotics
J C OnishiM B Kurtz

Abstract

A family of aminoacyl alkyl citrate compounds called viridiofungins, are novel squalene synthase inhibitors. The compounds have broad spectrum fungicidal activity but lack antibacterial activity. Although the compounds inhibit squalene synthase, the first committed step in ergosterol biosynthesis, results presented in this paper show that inhibition of fungal growth is not related to inhibition of ergosterol synthesis.

Citations

Apr 28, 2005·Chemical Communications : Chem Comm·Kenji MorokumaSusumi Hatakeyama
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Toshihide KobayashiYoshio Hirabayashi
Sep 28, 2017·The Journal of Antibiotics·Naoya Kumagai, Masakatsu Shibasaki
Jan 25, 2014·Organic & Biomolecular Chemistry·Mark A Rizzacasa, Dayna Sturgess
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Jul 29, 2017·Organic & Biomolecular Chemistry·Masatoshi Murakata, Takuma Ikeda
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