Antimicrobial and Antibiofilm Activity and Machine Learning Classification Analysis of Essential Oils from Different Mediterranean Plants against Pseudomonas aeruginosa

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Marco ArtiniLaura Selan

Abstract

Pseudomonas aeruginosa is a ubiquitous organism and opportunistic pathogen that can cause persistent infections due to its peculiar antibiotic resistance mechanisms and to its ability to adhere and form biofilm. The interest in the development of new approaches for the prevention and treatment of biofilm formation has recently increased. The aim of this study was to seek new non-biocidal agents able to inhibit biofilm formation, in order to counteract virulence rather than bacterial growth and avoid the selection of escape mutants. Herein, different essential oils extracted from Mediterranean plants were analyzed for their activity against P. aeruginosa. Results show that they were able to destabilize biofilm at very low concentration without impairing bacterial viability. Since the action is not related to a bacteriostatic/bactericidal activity on P. aeruginosa, the biofilm change of growth in presence of the essential oils was possibly due to a modulation of the phenotype. To this aim, application of machine learning algorithms led to the development of quantitative activity-composition relationships classification models that allowed to direct point out those essential oil chemical components more involved in the inhibition ...Continue Reading

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Citations

Mar 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandros PatsilinakosRino Ragno
Jan 30, 2020·Current Drug Targets·Usha K RoutGaurav R Dwivedi
Oct 12, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandra OlivaRino Ragno
Feb 25, 2020·Interdisciplinary Perspectives on Infectious Diseases·Mohamed EladawyRasha Barwa
May 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuela SabatinoRino Ragno
Dec 1, 2020·Critical Reviews in Food Science and Nutrition·Chiara RossiAntonello Paparella
May 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Milica PejčićNiko Radulović
Sep 2, 2021·Saudi Journal of Biological Sciences·Khaled A El-TarabilyMohamed E Abd El-Hack

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