Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola

BMC Complementary and Alternative Medicine
Raissa Tioyem NzogongJean-de-Dieu Tamokou

Abstract

Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases. The plant extracts were prepared by maceration in ethanol. Standard chromatographic and spectroscopic methods were used to isolate and identify fourteen compounds from the two plant species [1-6 (from D. senegambiensis), 3, 4 and 7-14 (from A. monticola)]. A two-fold serial micro-dilution method was used to determine the minimum inhibitory concentration (MIC) against four bacterial strains including two resistant bacterial strains, methicillin resistant S. aureus (MRSA3) and methicillin resistant S. aureus (MRSA4) and three yeast strains. The fractionation of EtOH extracts afforded fourteen compounds belonging to triterpenoid and phenolic derivatives. The ethanol extracts, compounds 3, 5-8, 10 and the mixture of 10 + 12 were active against all the tested bacterial and fungal species. Compound 7 (MIC = 16-32 μg/mL) and 10 (MIC = 8-...Continue Reading

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Citations

Dec 7, 2018·Critical Reviews in Food Science and Nutrition·Jiao LiTian Ding
Mar 14, 2019·Frontiers in Plant Science·Xin ZhouMingjie Chen
Nov 19, 2020·Natural Product Research·Judith Flore T MbougniaNorbert Sewald
May 21, 2020·Current Drug Targets·Aditi SharmaVikas Jaitak
Jun 7, 2021·BMC Complementary Medicine and Therapies·Irene Chinda KengneJean-De-Dieu Tamokou
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Piman PocasapRawiwan Wongpoomchai
Aug 28, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Najwan JubairAyesha Fatima

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Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

Statistical Package for Social Sciences ( SPSS

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