Antimicrobial and antioxidant activities of hydrocarbon and oxygenated monoterpenes against some foodborne pathogens through in vitro and in silico studies

Pesticide Biochemistry and Physiology
Mohamed E I BadawyNehad E M Taktak

Abstract

The present work describes the antimicrobial action of 25 monoterpenes (six hydrocarbons, five ketones, two aldehydes, six alcohols and six acetate analogues) against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus and antifungal activity against Aspergillus flavus. The antibacterial activity was evaluated by broth microdilution technique as a minimum inhibitory concentration (MIC) and the antifungal activity was performed by mycelia radial growth technique as the effective concentration causing 50% inhibition of the mycelial growth (EC50). The results showed that thymol and α-terpineol were the most potent against E. coli (MIC = 45 and 55 mg/L, respectively) and S. aureus (MIC = 135 and 225 mg/L, respectively). The results also showed that thymol displayed the maximum antifungal action against A. flavus with EC50 20 mg/L. Furthermore, the antioxidant activity was determined using N,N-dimethyl-1,4-phenylenediamine (DMPD) and the results showed that geraniol were the most potent compound (IC50 = 19 mg/L). Molecular docking studies indicated that the compounds displayed different binding interactions with the amino acid residues at the catalytic sites of N5-carboxyaminoimidazole synthetase and oxysterol bin...Continue Reading

Citations

Jun 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Dolores IbáñezMaría Amparo Blázquez
Oct 1, 2020·International Journal of Molecular Sciences·Paweł KwiatkowskiBarbara Dołęgowska
Nov 10, 2020·Chemical Reviews·Gina PorrasCassandra L Quave
Nov 6, 2020·ACS Applied Materials & Interfaces·Sara Garcia-SalinasGracia Mendoza

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