Antimicrobial and beta-lactamase inhibitory activities of carpetimycins A and B, new carbapenem antibiotics.

Antimicrobial Agents and Chemotherapy
F KobayashiS Mitsuhashi

Abstract

Carpetimycins A and B showed widely broad spectra and potent activity against gram-positive and gram-negative bacteria, including various species of anaerobic bacteria. The antimicrobial activity of carpetimycin A was 8 to 64 times greater than that of carpetimycin B and 4 to 128 times greater than that of cefoxitin. The inhibitory concentration of carpetimycin A required to inhibit more than 90% of clinical isolates was 0.39 micrograms/ml for Escherichia coli and klebsiella and 1.56 microgram/ml for Proteus and Staphylococcus aureus. At a concentration of 3.13 micrograms/ml, carpetimycin A inhibited almost all clinical isolates of Enterobacter and Citrobacter, which showed resistance to many clinically used beta-lactam antibiotics. Carpetimycins A and B furthermore were shown to have potent inhibitory activities against several kinds of beta-lactamases produced by beta-lactam-resistant strains; they inhibited not only penicillinase-type beta-lactamases but also cephalosporinase-type beta-lactamases, which were insensitive to clavulanic acid. In combination with beta-lactam antibiotics such as ampicillin, carbenicillin, and cefazolin, carpetimycins A and B showed synergistic activities against beta-lactam-resistant bacteria.

References

Jan 1, 1976·Antimicrobial Agents and Chemotherapy·Y SawadaS Mitsuhashi
May 1, 1977·Antimicrobial Agents and Chemotherapy·C Reading, M Cole
Mar 1, 1980·Antimicrobial Agents and Chemotherapy·K HiraiS Mitsuhashi
Jul 1, 1981·The Journal of Antibiotics·K TanakaT Yoshida
Feb 1, 1981·The Journal of Antibiotics·Y NozakiA Imada
Nov 1, 1980·The Journal of Antibiotics·M NakayamaT Mori
Jul 1, 1981·The Journal of Antibiotics·M NakayamaT Kawasaki
Aug 1, 1980·The Journal of Antibiotics·K YamamotoT Ishikura
Aug 1, 1953·The Biochemical Journal·M DIXON

❮ Previous
Next ❯

Citations

Aug 24, 2011·Antimicrobial Agents and Chemotherapy·Krisztina M Papp-WallaceRobert A Bonomo
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·Y SainoS Mitsuhashi
Sep 1, 1984·Antimicrobial Agents and Chemotherapy·M FuksaA Lee
Mar 1, 1993·Antimicrobial Agents and Chemotherapy·L L Silver, K A Bostian
Apr 2, 2002·Expert Opinion on Investigational Drugs·Giovanni BonfiglioGiuseppe Nicoletti
Jan 1, 1992·Critical Reviews in Biotechnology·H H GadebuschS B Zimmerman
Oct 1, 1983·Medicinal Research Reviews·S J Cartwright, S G Waley
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Malcolm G. P. Page

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.