Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia

Antimicrobial Agents and Chemotherapy
Brandon J H BanaschewskiRuud A W Veldhuizen

Abstract

Antibiotic-resistant bacterial infections represent an emerging health concern in clinical settings, and a lack of novel developments in the pharmaceutical pipeline is creating a "perfect storm" for multidrug-resistant bacterial infections. Antimicrobial peptides (AMPs) have been suggested as future therapeutics for these drug-resistant bacteria, since they have potent broad-spectrum activity, with little development of resistance. Due to the unique structure of the lung, bacterial pneumonia has the additional problem of delivering antimicrobials to the site of infection. One potential solution is coadministration of AMPs with exogenous surfactant, allowing for distribution of the peptides to distal airways and opening of collapsed lung regions. The objective of this study was to test various surfactant-AMP mixtures with regard to maintaining pulmonary surfactant biophysical properties and bactericidal functions. We compared the properties of four AMPs (CATH-1, CATH-2, CRAMP, and LL-37) suspended in bovine lipid-extract surfactant (BLES) by assessing surfactant-AMP mixture biophysical and antimicrobial functions. Antimicrobial activity was tested against methillicin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Al...Continue Reading

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Citations

Oct 26, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Cristina Prat, Alicia Lacoma
Jun 5, 2020·Lipids in Health and Disease·Christina W AgudeloItsaso Garcia-Arcos
Jun 12, 2020·Scientific Reports·Brandon BaerRuud Veldhuizen
Nov 28, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alberto HidalgoJesús Pérez-Gil
Feb 6, 2021·Frontiers in Bioengineering and Biotechnology·Cristina García-MoutonJesús Pérez-Gil
Jan 10, 2021·Journal of Clinical Medicine·Adam FabisiakJakub Fichna
Jun 21, 2021·Biochimica Et Biophysica Acta. General Subjects·Martin van EijkHenk P Haagsman
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Aug 28, 2021·Antibiotics·Lucía FernándezPilar García
May 30, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Brandon BanaschewskiThomas Hofmann

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