Abstract
Six compounds, namely, Lupeol (1), Betulin (2), beta-Taraxerol (3), Taraxerone (4), Stigmasterol (5) and beta-Sitosterol (6) were isolated from the petroleum ether extract of the leaves of Sapium baccatum based on spectroscopic evidence. Lupeol (1), Betulin (2) and Stigmasterol (5) were isolated for the first time from this plant. The cytotoxic potential of the different solvent extracts (methanol, petroleum ether, carbon-tetrachloride and dichloromethane); six column fractions (F-4, F-7, F-10, F-12, F-18 and F-22) of petroleum ether extract and three pure compounds 1, 4 and 6 were determined by using brine shrimp lethality bioassay. The LC50 of all the tested samples were showed to be lethal to brine shrimp nauplii. However, petroleum ether, carbon-tetrachloride extract, column fractions F-4 and F-18 of petroleum ether extract and pure compound 6 showed quite potent activity in brine shrimp lethality bioassay with LC50 1.33, 1.35, 1.40, 1.58 and 1.58 microg/ml, respectively. These result suggested that they might be contain antitumor or pesticidal activity. Further, the methanol extract and four column fractions (F-7, F-12, F-18 and F-22) of petroleum ether showed significant activity against the tested microorganisms.
References
Mar 1, 1992·Journal of Natural Products·G ZhaoK V Wood
Jun 1, 1991·Postgraduate Medical Journal·I H Khan
Feb 1, 1996·Journal of Natural Products·M J RieserJ L McLaughlin
Jul 12, 2002·Phytotherapy Research : PTR·E MongelliG Martínez Massanet
May 1, 1982·Planta medica·B N MeyerJ L McLaughlin
Citations
Mar 14, 2012·Journal of Natural Products·Hong-Bing LiuJian-Min Yue
Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Rosa Moo-PucEdgar Caamal-Fuentes
Apr 23, 2011·Journal of Economic Entomology·D D DuanG L Shi
Dec 2, 2010·Life Sciences·Hifzur Rahman Siddique, Mohammad Saleem
Jun 17, 2015·BioMed Research International·Chunya BuYounian Wang
Apr 29, 2014·Pharmaceutical Biology·Latifah Saiful Yazan, Nurdin Armania
Jul 15, 2015·BMC Complementary and Alternative Medicine·Olubunmi Adenike OmoyeniEmmanuel Iwuoha
May 5, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chang-Keun SungEun-Kyoung Mo
Sep 11, 2013·Journal of Ethnopharmacology·L M R Al MuqarrabunI Sahidin
Jun 1, 2014·Journal of Ethnopharmacology·L M R Al MuqarrabunS Ruzaina S Aris
Apr 5, 2014·Natural Product Research·L M Ramadhan Al MuqarrabunFatimah Salim
Jun 14, 2016·Journal of Pathogens·Jackie K ObeyCarina Tikkanen-Kaukanen
Jul 26, 2017·PloS One·Thuy Thu VuJin-Cheol Kim
Jan 22, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malwina ChudzikWojciech Król
Apr 28, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sakina SaadawiIbrahim Jantan
Dec 4, 2016·Applied Biochemistry and Biotechnology·Musarat AminaMyung-Seob Khil
Jul 10, 2018·Journal of Pathogens·Jackie K ObeyCarina Tikkanen-Kaukanen
Apr 12, 2021·Phytochemistry·Masaaki NojiAkemi Umeyama
May 18, 2021·Journal of Ethnopharmacology·Qiaobian HePeihong Fan
Oct 24, 2018·Journal of Natural Products·Gui-Jie ZhangDong Liang