Antimicrobial and cytotoxic constituents from leaves of Sapium baccatum

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Yunus AhmedM A Sattar

Abstract

Six compounds, namely, Lupeol (1), Betulin (2), beta-Taraxerol (3), Taraxerone (4), Stigmasterol (5) and beta-Sitosterol (6) were isolated from the petroleum ether extract of the leaves of Sapium baccatum based on spectroscopic evidence. Lupeol (1), Betulin (2) and Stigmasterol (5) were isolated for the first time from this plant. The cytotoxic potential of the different solvent extracts (methanol, petroleum ether, carbon-tetrachloride and dichloromethane); six column fractions (F-4, F-7, F-10, F-12, F-18 and F-22) of petroleum ether extract and three pure compounds 1, 4 and 6 were determined by using brine shrimp lethality bioassay. The LC50 of all the tested samples were showed to be lethal to brine shrimp nauplii. However, petroleum ether, carbon-tetrachloride extract, column fractions F-4 and F-18 of petroleum ether extract and pure compound 6 showed quite potent activity in brine shrimp lethality bioassay with LC50 1.33, 1.35, 1.40, 1.58 and 1.58 microg/ml, respectively. These result suggested that they might be contain antitumor or pesticidal activity. Further, the methanol extract and four column fractions (F-7, F-12, F-18 and F-22) of petroleum ether showed significant activity against the tested microorganisms.

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Citations

Mar 14, 2012·Journal of Natural Products·Hong-Bing LiuJian-Min Yue
Jul 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Rosa Moo-PucEdgar Caamal-Fuentes
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May 5, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chang-Keun SungEun-Kyoung Mo
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May 18, 2021·Journal of Ethnopharmacology·Qiaobian HePeihong Fan

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