Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium

Fitoterapia
Michel Feussi TalaPierre Tane

Abstract

Bioassay guided fractionation of Hypericum riparium leaves extract has resulted in the isolation and characterization of three new compounds namely chipericumin E (1), hyperenone C (3), and hyperixanthone (5), together with twenty known compounds. Their structures were elucidated based on comprehensive interpretation of spectroscopic and spectrometric data. Compounds 1-4, and 6-8 displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxic effects on the human gastric cell line BGC-823 with IC50 values ranging from 6.54 to 18.50μM.

References

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Jun 16, 2014·Phytochemistry·Serge Alain Fobofou TanemossuLudger A Wessjohann

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Citations

Feb 18, 2016·Phytochemistry·Serge Alain Tanemossu FobofouLudger A Wessjohann
Dec 29, 2016·Phytochemical Analysis : PCA·Michel Feussi TalaPierre Tane
Oct 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanyuan JiChunlin Long
Aug 29, 2018·Phytochemistry·Henrique BridiGilsane Lino von Poser
Feb 21, 2018·Chemical Reviews·Xing-Wei YangGang Xu

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