Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gamma-induced tryptophan degradation

FEMS Immunology and Medical Microbiology
Kathrin HeselerW Däubener

Abstract

Pneumonia caused by bacterial, viral and parasitic pathogens is one of the most common clinical problems facing primary and secondary care physicians. Staphylococcus aureus is a common cause of lung abscesses in humans and, in immunocompromised patients, herpes simplex virus type I and Toxoplasma gondii can cause severe life-threatening pneumonia. The authors focused their interest in the antimicrobial effects mediated by human lung cells against these pathogens. It was found that IFN-gamma-stimulated lung cells are capable of inhibiting T cell proliferation and restrict the replication of microorganisms such as T. gondii, S. aureus and herpes simplex virus. This immunoregulatory and antimicrobial effect was enhanced in the presence of IL-1 or tumor necrosis factor-alpha (TNF-alpha). Furthermore, the IFN-gamma-dependent antimicrobial effects of HBE4-E6/E7 (human lung bronchus epithelial cells) and A549 (human type II alveolar cells) correlated with the activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO). It was found that both the abrogation of IDO activity by the specific IDO-inhibitor 1-L-methyltryptophan and the supplementation of cultures with tryptophan result in an inhibition of IFN-gamma-induc...Continue Reading

References

Aug 1, 1977·The Journal of protozoology·E R Pfefferkorn, L C Pfefferkorn
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E R Pfefferkorn
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·L D SibleyI R Niesman
Jan 12, 1994·Journal of Immunological Methods·W DäubenerU Hadding
Sep 3, 1998·Journal of Neuroimmunology·C R MackenzieW Däubener
May 4, 1999·The Journal of Experimental Medicine·D H MunnA L Mellor
Oct 26, 1999·Infection and Immunity·W DäubenerC R MacKenzie
Sep 29, 2001·Nature Immunology·C Bogdan
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Jul 16, 2004·The Journal of Clinical Investigation·Tomoko HayashiEyal Raz
May 28, 2005·Journal of Virology·Karola ObojesJürgen Schneider-Schaulies
Dec 20, 2005·Viral Immunology·Masanori Terajima, Anita M Leporati

❮ Previous
Next ❯

Citations

Mar 21, 2013·Journal of Clinical Immunology·H I BaxE P Sampaio
Jul 22, 2009·Infection and Immunity·Katrin SpekkerWalter Däubener
Feb 2, 2010·American Journal of Respiratory Cell and Molecular Biology·Sara A PaveglioMatthew E Poynter
May 18, 2013·Virology Journal·Megan A O'Connor, William R Green
Sep 28, 2010·Amino Acids·Nathalie Le Floc'hElodie Merlot
Jul 9, 2014·Scandinavian Journal of Gastroenterology·Arnold BerstadJørgen Valeur
Jun 19, 2009·Expert Opinion on Therapeutic Targets·P H Tan, A K Bharath
Dec 23, 2015·Future Medicinal Chemistry·Francesco Antonio GrecoAntonio Macchiarulo
Mar 1, 2016·Neuropharmacology·Nicholas H HuntHelen J Ball
Jul 4, 2008·Current Opinion in Microbiology·Eric BarteeGrant McFadden
Jul 29, 2009·European Journal of Immunology·Silvia K SchmidtWalter Däubener
Aug 15, 2012·Immunological Reviews·Tracy L McGahaAndrew L Mellor
Sep 23, 2014·International Journal of Medical Microbiology : IJMM·Dirk SchlüterCarsten Lüder
Nov 7, 2012·Current Opinion in Allergy and Clinical Immunology·Annika Luukkainen, Sanna Toppila-Salmi
Apr 23, 2013·Innate Immunity·Elisa WirthgenEllen Kanitz
Aug 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masato HoshiMitsuru Seishima
Jul 4, 2019·Medical Microbiology and Immunology·Katrin Spekker-BoskerSilvia Kathrin Eller
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason C O'ConnorKeith W Kelley
Mar 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masato HoshiKuniaki Saito
Feb 20, 2019·International Journal of Molecular Sciences·Katrin Spekker-BoskerSilvia Kathrin Eller
Nov 13, 2020·Frontiers in Cellular and Infection Microbiology·Debanjan MukhopadhyayJeroen P J Saeij
May 20, 2020·International Journal of Medical Microbiology : IJMM·Sofia A Tsvetikova, Elena I Koshel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.