Antimicrobial and Structural Properties of Metal Ions Complexes with Thiosemicarbazide Motif and Related Heterocyclic Compounds

Current Medicinal Chemistry
Ewelina NamiecińskaElzbieta Budzisz

Abstract

Antibiotic resistance acquired by various bacterial fungal and viral pathogens poses therapeutic problems of increasing severity. Among the infections that are very difficult to treat, biofilm-associated cases are one of the most hazardous. Complex structure of a biofilm and unique physiology of the biofilm cells contribute to their extremely high resistance to environmental conditions, antimicrobial agents and the mechanisms of host immune response. Therefore, the biofilm formation, especially by multidrugresistant pathogens, is a serious medical problem, playing a pivotal role in the development of chronic and recurrent infections. These factors create a limitation for using traditional chemiotherapeutics and contribute to a request for development of new approaches for treatment of infectious diseases. Therefore, early reports on antimicrobial activity of several complexes of metal ions, bearing thiosemicarbazide or thiosemicarbazones as the ligands, gave a boost to worldwide search for new, more efficient compounds of this class, to be used as alternatives to commonly known drugs. In general, depending on the presence of other heteroatoms, these ligands may function in a di-, tri- or tetradentate forms (e.g., of N,S,-, N,N,...Continue Reading

References

Oct 1, 1991·Mayo Clinic Proceedings·A J Wright, C J Wilkowske
Jul 1, 1973·Antimicrobial Agents and Chemotherapy·E KatzN Goldblum
May 30, 2001·Journal of Inorganic Biochemistry·P J BlowerY Zheng
May 4, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael Barza, Karin Travers
Apr 4, 2003·The New England Journal of Medicine·Soju ChangUNKNOWN Vancomycin-Resistant Staphylococcus aureus Investigative Team
Nov 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·R L THOMPSONG H HITCHINGS
Jul 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·M K BACH, W E MAGEE
Feb 3, 2004·Mini Reviews in Medicinal Chemistry·Heloisa Beraldo, Dinorah Gambino
Nov 30, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Hafsatou Ndama Traoré, Debra Meyer
Aug 24, 2005·Bioorganic & Medicinal Chemistry Letters·Tanushree Ratan BalDharmarajan Sriram
Sep 8, 2005·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sulekh Chandra, Lokesh Kumar Gupta
Dec 31, 2005·Pharmacological Reviews·Danuta S Kalinowski, Des R Richardson
Dec 8, 2007·European Journal of Medicinal Chemistry·Liliana M FinkielszteinAlbertina G Moglioni
Jun 2, 2009·Chemical & Pharmaceutical Bulletin·Shikha Parmar, Yatendra Kumar
Oct 10, 2009·European Journal of Medicinal Chemistry·Visnja VrdoljakMarina Cindrić
Feb 13, 2010·International Journal of Antimicrobial Agents·Niels HøibyOana Ciofu
Dec 3, 2010·Journal of Medicinal Chemistry·Giorgio PelosiElisabetta Pilotti
Mar 2, 2011·Bioorganic & Medicinal Chemistry Letters·Iou-Jiun KangJyh-Haur Chern
Jun 15, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sangamesh A PatilPrema S Badami
Jan 11, 2012·FEMS Microbiology Reviews·Sivan Elias, Ehud Banin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.