Antimicrobial, anticancer, and antioxidant compounds from Premna resinosa growing in Saudi Arabia

Pharmaceutical Biology
Dina A AlbadawiNawal M Almusayeib

Abstract

Premna resinosa (Hochst.) Schauer (Lamiaceae) is used in many places to treat bronchitis, respiratory illness and convulsions of the rib cage. This study evaluates the anticancer, antimicrobial and antioxidant activities of P. resinosa, and isolates some responsible constituents. The methanol extract of P. resinosa aerial parts and its fractions (n-hexane, dichloromethane, ethyl acetate and n-butanol) were tested. Antimicrobial activity was tested using microdilution method against three Gram-positive and four Gram-negative bacteria. The tested concentrations ranged from 4000 to 7.8 μg/mL and MIC values were determined after 24 h incubation. Anticancer activity was evaluated against three human cancer cell lines (Daoy, HepG2 and SK-MEL28) using MTT assay. Antioxidant activity was investigated by DPPH scavenging method and β-carotene-linoleic acid assay. The greatest antimicrobial activity was exhibited by n-hexane fraction (MIC 10 μg/mL) against Staphylococcus aureus, Enterococcus faecalis, and Shigella flexneri. The n-hexane fraction induced the greatest cytotoxic activity against Daoy, HepG2, and SK-MEL28 cell lines with IC50 values of 9.0, 8.5 and 13.2, respectively. Moreover, the dichloromethane and ethyl acetate fractions ...Continue Reading

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Citations

Jun 15, 2018·Molecular Medicine Reports·Qasem AbdallahAmin Abdulmajid
Jun 4, 2019·Frontiers in Microbiology·Leen OthmanRoula M Abdel-Massih
Aug 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chandrashekhar SinghVijay Kumar

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Methods Mentioned

BETA
nuclear magnetic resonance
column chromatography
NMR

Software Mentioned

SPSS

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