Abstract
Premna resinosa (Hochst.) Schauer (Lamiaceae) is used in many places to treat bronchitis, respiratory illness and convulsions of the rib cage. This study evaluates the anticancer, antimicrobial and antioxidant activities of P. resinosa, and isolates some responsible constituents. The methanol extract of P. resinosa aerial parts and its fractions (n-hexane, dichloromethane, ethyl acetate and n-butanol) were tested. Antimicrobial activity was tested using microdilution method against three Gram-positive and four Gram-negative bacteria. The tested concentrations ranged from 4000 to 7.8 μg/mL and MIC values were determined after 24 h incubation. Anticancer activity was evaluated against three human cancer cell lines (Daoy, HepG2 and SK-MEL28) using MTT assay. Antioxidant activity was investigated by DPPH scavenging method and β-carotene-linoleic acid assay. The greatest antimicrobial activity was exhibited by n-hexane fraction (MIC 10 μg/mL) against Staphylococcus aureus, Enterococcus faecalis, and Shigella flexneri. The n-hexane fraction induced the greatest cytotoxic activity against Daoy, HepG2, and SK-MEL28 cell lines with IC50 values of 9.0, 8.5 and 13.2, respectively. Moreover, the dichloromethane and ethyl acetate fractions ...Continue Reading
References
Jun 20, 1998·Journal of Applied Microbiology·C M Mann, J L Markham
Oct 2, 2002·Bioscience, Biotechnology, and Biochemistry·Hidetoshi Arima, Gen-ichi Danno
Dec 24, 2004·Journal of Medicinal Chemistry·Louis J LombardoRobert M Borzilleri
Dec 23, 2006·European Journal of Pharmacology·Victoria García-MediavillaJavier González-Gallego
Jan 23, 2009·Journal of Cellular Biochemistry·Gabriella MarfeMatteo Antonio Russo
Aug 25, 2009·Bioorganic & Medicinal Chemistry Letters·A HymavathiJ Madhusudana Rao
Sep 17, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Isha DhamijaK S R Pai
Mar 16, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H TalibAdel M Mahasneh
Jun 28, 2012·Toxicology International·Thamizh N SelvamPreetham Elumalai
Feb 16, 2013·Journal of Agricultural and Food Chemistry·Jian-ye ZhangHu-biao Chen
Mar 16, 2013·Journal of Young Pharmacists : JYP·Za MahmudN Qais
Nov 5, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Naidu V G MRamakrishna Sistla
Aug 26, 2015·BMC Complementary and Alternative Medicine·Sospeter Ngoci NjeruSilas Mwaniki Ngari
Jan 1, 1992·American Journal of Human Biology : the Official Journal of the Human Biology Council·Kathleen A Galvin
Citations
Jun 15, 2018·Molecular Medicine Reports·Qasem AbdallahAmin Abdulmajid
Aug 12, 2018·BMC Complementary and Alternative Medicine·Ramzi A MothanaMine Kurkcuoglu
Jun 4, 2019·Frontiers in Microbiology·Leen OthmanRoula M Abdel-Massih
Feb 20, 2020·Current Drug Delivery·Saleh Ayed AlanaziFars Kaed Alanazi
Aug 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chandrashekhar SinghVijay Kumar
Apr 23, 2021··Binawati GintingMustanir