Antimicrobial dialkylresorcinols from Pseudomonas sp. Ki19

Journal of Natural Products
Anton PohankaAnders Broberg

Abstract

Four dialkylresorcinols (1-4) were isolated from a liquid culture of Pseudomonas sp. Ki19. Compounds 1 and 2, 2-butyl-5-propylresorcinol and 2-hexyl-5-methylresorcinol, respectively, have not previously been isolated from biological sources, whereas 3 and 4, 2-hexyl-5-propylresorcinol (DB-2073) and 2-hexyl-5-pentylresorcinol (resorstatin), both have been found in biological systems. The compounds inhibited Staphyllococcus aureus at concentrations < or = 10 microg/mL as well as the fungi Aspergillus fumigatus and Fusarium culmorum at 50 microg/mL. The formation of possible antimicrobial quinone oxidation products was investigated under bioassay conditions, and they were not found to be responsible for the main antimicrobial activity.

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Sep 27, 2005·Journal of Natural Products·Anton PohankaJolanta Levenfors

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Citations

Oct 12, 2012·Pharmacognosy Reviews·Sudha VengurlekarPiyush Trivedi
Jan 3, 2013·Molecular Plant Pathology·Barbara SchermQuirico Migheli
Aug 15, 2015·Applied Microbiology and Biotechnology·Tim A SchönerHelge B Bode
Mar 20, 2018·Natural Product Research·Jinzhong XuPinmei Wang
Feb 1, 2019·Natural Product Reports·Teresa P MartinsPedro N Leão
Dec 7, 2007·Phytotherapy Research : PTR·Guillermo Schmeda-HirschmannGabriela Egly Feresin
Oct 2, 2009·Organic & Biomolecular Chemistry·Jacqueline PoldyRussell Allan Barrow
Aug 12, 2020·The Journal of Antibiotics·Jianye LiBenjamin R Clark

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