Dec 1, 1975

Antimicrobial effect of simple lipids and the effect of pH and positive ions

Antimicrobial Agents and Chemotherapy
K LarssonG Odham


Various branched fatty acids, particularly those of iso-configuration, have been shown to possess fungistatic and bacteriostatic properties. On the basis of their swelling effect on hyphae of Fusarium roseum it was suggested that this is due to an increase in the permeability of the plasma membrane. The solubilization of fatty acids in membranes should be expected to be influenced by the degree of dissociation and the presence of counter ions. Therefore, the effects of pH and K(+), Na(+), and Ca(2+) ions were studied. It is demonstrated that the presence of the univalent ions, Na(+) and K(+), markedly enhances the fungistatic effect of iso-tetradecanoic acid, whereas the opposite effect is noted for the divalent ion, Ca(2+). The effects are particularly pronounced at high pH. Furthermore, the antimicrobial effect obtained from the combination of fatty acid and tetramethylthiuramdisulfide is significantly enhanced in the presence of 0.1 and 0.2% KCl.

  • References2
  • Citations2


  • References2
  • Citations2

Mentioned in this Paper

Tissue Membrane
Antimicrobial Effect
Fusarium graminearum
Fatty Acids
Lipids Measurement

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