PMID: 9438063Jan 23, 1998Paper

Antimicrobial effect on rabbit sinusitis after temporary ostial occlusion

American Journal of Rhinology
D J BesteA Kajdacsy-Balla

Abstract

A key precipitating factor in the pathogenesis of acute bacterial sinusitis (ABS) is ostiomeatal obstruction. It has been postulated that ABS cannot resolve until the sinus ostium is patent. The primary purpose of this study is to quantify sinusitis resolution after temporary ostial occlusion in a rabbit model. A secondary aim is to quantify bacterial clearance with and without antimicrobial therapy in Staphylococcus aureus infected sinuses. A blinded, placebo controlled study in 10 New Zealand white rabbits was performed using Merocel as a temporary maxillary sinus ostial obstruction. Computerized tomography (CT) of the maxillary sinuses was obtained before and after bilateral ostial occlusion; sinuses were cultured and then the left sinus was injected with approximately 10(8) cfu/mL S. aureus. CT imaging and sinus cultures were obtained and then the ostial plugs were removed. Serial CT and cultures were done until sinusitis resolved and cultures were negative for S. aureus. Mean CT sinusitis scores increased with ostial obstruction and decreased with ostial plug removal (P < 0.0001 and P < 0.001). Injection of S. aureus did not significantly change mean CT sinusitis scores despite being cultured from 45% of sinuses. Antimicro...Continue Reading

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Citations

Oct 7, 2004·Current Allergy and Asthma Reports·Cüneyt O Kara
Feb 3, 2004·The Laryngoscope·Cüneyt Orhan KaraEmre Pakdemirli
Jan 5, 2018·Laryngoscope Investigative Otolaryngology·Ahmed A Al-SayedEmad Massoud
Jan 20, 2011·American Journal of Rhinology & Allergy·Il Gyu KangSeon Tae Kim
May 9, 2019·Journal of the American Veterinary Medical Association·Noémie M SummaGeraldine B Hunt

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