Abstract
In an in vitro dynamic model we compared the antimicrobial effects of two carbapenems, imipenem (MIC, 1 microg/ml) and meropenem (MIC, 0.25 microg/ml) on Pseudomonas aeruginosa. The antibiotics were administered either as short-time infusions once or three times a day or as continuous infusions with steady-state levels ranging from 0.5 to 20 microg/ml. From the resulting kill curves the period of time until the onset of bacterial death (dt), the rate constant of bacterial death (ka), the maximal reduction of CFU (mr), and the period of time until bacterial regrowth occurred (tr) were determined. Additionally, the occurrence of bacterial resistance during the simulations (rq) and the postantibiotic effect (PAE) were recorded. For both investigated carbapenems no significant difference in dt, ka, mr, and PAE values between the short-time infusions and continuous infusions with steady-state levels above 2 microg/ml could be detected. The tr was longest with continuous infusions of over approximately 24 h, corresponding to steady-state levels of 3 microg/ml for imipenem and 2.5 microg/ml for meropenem. An increase in MIC was observed only during continuous infusions with steady-state levels below 2 microg/ml. Independent of the cho...Continue Reading
References
Oct 1, 1992·Antimicrobial Agents and Chemotherapy·D ParadisM LeBel
Dec 1, 1992·Antimicrobial Agents and Chemotherapy·W A Craig, S C Ebert
Jul 1, 1992·Antimicrobial Agents and Chemotherapy·S A SignsT M File
Jul 1, 1992·Antimicrobial Agents and Chemotherapy·B A ChristenssonS R Norrby
Sep 1, 1991·Antimicrobial Agents and Chemotherapy·U FlückigerA U Gerber
Jun 24, 1989·Lancet·T J David, J Devlin
Dec 1, 1986·The Journal of Antimicrobial Chemotherapy·R WiseJ M Andrews
Feb 1, 1987·Antimicrobial Agents and Chemotherapy·C ThauvinR C Moellering
Sep 1, 1986·Antimicrobial Agents and Chemotherapy·R RoosendaalM F Michel
Dec 1, 1983·The Journal of Antimicrobial Chemotherapy·F M KahanJ Birnbaum
Oct 1, 1984·European Journal of Clinical Microbiology·G L DrusanoS C Schimpff
Nov 1, 1984·Antimicrobial Agents and Chemotherapy·G L DrusanoS C Schimpff
Apr 1, 1984·European Journal of Clinical Microbiology·I A Bakker-WoudenbergM F Michel
Mar 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S DaenenM R Halie
May 1, 1995·Antimicrobial Agents and Chemotherapy·S Keil, B Wiedemann
May 1, 1994·Antimicrobial Agents and Chemotherapy·J W Mouton, J G den Hollander
Jun 1, 1993·The Journal of Antimicrobial Chemotherapy·I Odenholt-Tornqvist
Citations
Oct 6, 2000·Clinical Pharmacokinetics·J W MoutonA A Vinks
Jan 5, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Seigo HidakaTakayuki Noguchi
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Ben M Lomaestro, G L Drusano
Nov 20, 1998·Journal of Chemotherapy·I M Gould
Feb 2, 2006·The Annals of Pharmacotherapy·Leonardo LorenteMaría L Mora
Jul 15, 2016·Clinical Microbiology Reviews·Mordechai GrupperDavid P Nicolau
Oct 23, 2019·Antimicrobial Agents and Chemotherapy·Rajbharan YadavCornelia B Landersdorfer
Jun 1, 1999·The Journal of Antimicrobial Chemotherapy·F ThalhammerH Burgmann
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·F ThalhammerK Ratheiser
Mar 23, 2004·Journal of Chemical Information and Computer Sciences·Enrique MolinaEugenio Uriarte