PMID: 9174173Jun 1, 1997Paper

Antimicrobial effects of continuous versus intermittent administration of carbapenem antibiotics in an in vitro dynamic model

Antimicrobial Agents and Chemotherapy
S Keil, B Wiedemann

Abstract

In an in vitro dynamic model we compared the antimicrobial effects of two carbapenems, imipenem (MIC, 1 microg/ml) and meropenem (MIC, 0.25 microg/ml) on Pseudomonas aeruginosa. The antibiotics were administered either as short-time infusions once or three times a day or as continuous infusions with steady-state levels ranging from 0.5 to 20 microg/ml. From the resulting kill curves the period of time until the onset of bacterial death (dt), the rate constant of bacterial death (ka), the maximal reduction of CFU (mr), and the period of time until bacterial regrowth occurred (tr) were determined. Additionally, the occurrence of bacterial resistance during the simulations (rq) and the postantibiotic effect (PAE) were recorded. For both investigated carbapenems no significant difference in dt, ka, mr, and PAE values between the short-time infusions and continuous infusions with steady-state levels above 2 microg/ml could be detected. The tr was longest with continuous infusions of over approximately 24 h, corresponding to steady-state levels of 3 microg/ml for imipenem and 2.5 microg/ml for meropenem. An increase in MIC was observed only during continuous infusions with steady-state levels below 2 microg/ml. Independent of the cho...Continue Reading

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Citations

Oct 6, 2000·Clinical Pharmacokinetics·J W MoutonA A Vinks
Jan 5, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Seigo HidakaTakayuki Noguchi
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Ben M Lomaestro, G L Drusano
Nov 20, 1998·Journal of Chemotherapy·I M Gould
Jul 15, 2016·Clinical Microbiology Reviews·Mordechai GrupperDavid P Nicolau
Jun 1, 1999·The Journal of Antimicrobial Chemotherapy·F ThalhammerH Burgmann
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·F ThalhammerK Ratheiser
Mar 23, 2004·Journal of Chemical Information and Computer Sciences·Enrique MolinaEugenio Uriarte

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