Antimicrobial Efficacy of a Historical High-Frequency Plasma Apparatus in Comparison With 2 Modern, Cold Atmospheric Pressure Plasma Devices

Surgical Innovation
Georg DaeschleinMichael Jünger

Abstract

Today, highly sophisticated devices deliver cold atmospheric pressure plasma (CAPP) with a multitude of bioactive properties, opening the window to a new medical field: plasma medicine. Different techniques to create the optimal plasma device for different medical indications are currently being explored. However, even a 100 years ago, CAPP was briefly used in the related form of high-frequency therapy. The objective of our study was to compare historic with modern techniques regarding antimicrobial efficacy. First, 26 different clinical isolates of relevant wound pathogens were treated in vitro with a historic violet wand (VW) and 2 modern plasma sources (kINPen 09 and dielectric barrier discharge [DBD]) and the obtained inhibition areas (IAs) were compared. Second, a biofilm model was used to compare biofilm inactivation by VW, DBD, ethanol, and polyhexanide treatment. DBD with the largest electrode produced the largest IAs. VW showed results similar to 2 different modes of the kINPen 09. IAs of VW were enlargeable by attaching a larger electrode. Against biofilms, VW was less effective than DBD but more effective than ethanol 70% and polyhexanide. The proven antimicrobial efficacy of VW may encourage the development of new, ...Continue Reading

References

Jun 28, 2011·International Journal of Cancer. Journal International Du Cancer·Marc VandammeAlain Le Pape
Oct 8, 2011·British Journal of Cancer·M KeidarB Trink
Aug 14, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Julia HeinlinSigrid Karrer
Aug 21, 2013·Experimental Dermatology·Georg DaeschleinMichael Jünger
Mar 19, 2014·International Journal of Antimicrobial Agents·Anne Mai-ProchnowKostya Ken Ostrikov
Jun 27, 2014·International Orthopaedics·Maurice Hinsenkamp

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Citations

Sep 18, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Stefan HartwigJan Dirk Raguse
Oct 4, 2016·Journal of Medical Virology·M WeissM B Stope
Sep 13, 2018·Journal of Wound Care·Mina IzadjooJeffry Skiba
Feb 16, 2021·Applied Microbiology and Biotechnology·Bouke BoekemaEsther Middelkoop

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Methods Mentioned

BETA
chips

Software Mentioned

Tefra
kINPen

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