Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters

Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society
Paulina M KowalewskaAlison E Fox-Robichaud

Abstract

Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter lumen during locking. The objective of this study was to evaluate the antimicrobial efficacy of ChloraLock with in vitro tests and its ability to reduce Staphylococcus aureus contamination of catheters in the external jugular veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in the in vitro tests by up to 6 log10 colony-forming units (CFU) and by 3 to 4 log10 CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks.

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Citations

Aug 31, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Elif BalikciEkrem Kara

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Methods Mentioned

BETA
dissection
scanning electron microscopy

Software Mentioned

ChloraLock
Tescan VegaTC
Synergy
KaleidaGraph

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