Antimicrobial efficacy of an innovative emulsion of medium chain triglycerides against canine and feline periodontopathogens

The Journal of Small Animal Practice
G LavertyR Breathnach

Abstract

To test the in vitro antimicrobial efficacy of a non-toxic emulsion of free fatty acids against clinically relevant canine and feline periodontopathogens Antimicrobial kill kinetics were established utilising an alamarBlue(®) viability assay against 10 species of canine and feline periodontopathogens in the biofilm mode of growth at a concentration of 0·125% v/v medium chain triglyceride (ML:8) emulsion. The results were compared with 0·12% v/v chlorhexidine digluconate and a xylitol-containing dental formulation. Mammalian cellular cytotoxicity was also investigated for both the ML:8 emulsion and chlorhexidine digluconate (0·25 to 0·0625% v/v) using in vitro tissue culture techniques. No statistically significant difference was observed in the antimicrobial activity of the ML:8 emulsion and chlorhexidine digluconate; a high percentage kill rate (>70%) was achieved within 5 minutes of exposure and was maintained at subsequent time points. A statistically significant improvement in antibiofilm activity was observed with the ML:8 emulsion compared with the xylitol-containing formulation. The ML:8 emulsion possessed a significantly lower (P < 0·001) toxicity profile compared with the chlorhexidine digluconate in mammalian cellular...Continue Reading

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Citations

Jul 28, 2016·Antimicrobial Agents and Chemotherapy·S HoganE O'Neill
Jul 22, 2020·The Journal of General Virology·Nicola F FletcherAlan W Baird
Jul 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noureddine HallaMaria Filomena Barreiro

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