Antimicrobial efficacy of prophylactic gatifloxacin 0.3% and moxifloxacin 0.5% in patients undergoing phacoemulsification surgery

Eye & Contact Lens
Frank A BucciRuth E Evans

Abstract

To evaluate the ocular surface and aqueous antimicrobial effects of gatifloxacin and moxifloxacin administered in two dosing regimens to patients undergoing phacoemulsification. Patients were divided between two treatment groups and randomized to receive gatifloxacin 0.3% or moxifloxacin 0.5% within each group. Group 1 patients received antibiotics four times per day for 2 days before surgery with one additional drop the morning of surgery (n=50, each drug). Group 2 patients were treated as in group 1, plus four drops (one drop every 10 minutes) during the hour before surgery (n=60, each drug). Conjunctival and eyelid swabs were taken before surgery, and aqueous humor cultures were obtained immediately after surgery. Pathogens were identified and colony-forming units (CFUs) were counted. No differences were observed between the antibiotics in mean CFUs in conjunctival cultures from group 1 (gatifloxacin, 59.9+/-165.6 CFUs; moxifloxacin, 57.0+/-214.7 CFUs; P=0.939) or group 2 (gatifloxacin, 76.7+/-327.7 CFUs; moxifloxacin, 92.0+/-486.1 CFUs; P=0.830). No differences were observed between antibiotics in mean CFUs in eyelid cultures from group 1 (gatifloxacin, 198.1+/-330.1 CFUs; moxifloxacin, 168.3+/-379.0; P=0.840) or group 2 (g...Continue Reading

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Citations

Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Nov 4, 2010·Cornea·Thomas D LindquistMonty Montoya
Dec 9, 2014·Jundishapur Journal of Microbiology·Mahamoudreza PanahibazazEffat Abbasi Montazeri
Feb 20, 2013·Expert Opinion on Drug Delivery·Pravin PawarDipak K Majumdar
Mar 20, 2012·Archivos de la Sociedad Española de Oftalmología·C A WongJ J Rey
Apr 6, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Asser Ahmed Ehsan Abdel-MeguidTarek Mohamed Ibrahim Elmenofy
Mar 21, 2017·Journal of Cataract and Refractive Surgery·Ryohei NejimaKazunori Miyata

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