Antimicrobial Features of Organic Functionalized Graphene-Oxide with Selected Amines

Materials
Irina ZarafuPetre Ioniță

Abstract

(1) Background: Graphene oxide is a new carbon-based material that contains functional groups (carboxyl, hydroxyl, carbonyl, epoxy) and therefore can be easily functionalized with organic compounds of interest, yielding hybrid materials with important properties and applications. (2) Methods: Graphene oxide has been obtained by a modified Hummers method and activated by thionyl chloride in order to be covalently functionalized with amines. Thus obtained hybrid materials were characterized by infrared and Raman spectroscopy, elemental analysis and scanning electron microscopy and then tested for their antimicrobial and anti-biofilm activity. (3) Results: Eight amines of interest were used to functionalize grapheme oxide and the materials thus obtained were tested against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strainsin plankonic and biofilm growth state. Both amines, as well as the functionalized materials, exhibited anti-microbial features. Three to five functionalized graphene oxide materials exhibited improved inhibitory activity against planktonic strains as compared with the respective amines. In exchange, the amines alone proved generally more efficient ...Continue Reading

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Citations

Mar 22, 2019·Pharmaceutical Nanotechnology·Le HongQiang Peng
Sep 8, 2019·Journal of Orthopaedic Surgery and Research·Shizhou WuLei Lei
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Madalina TudoseDiana Iulia Savu
Jan 12, 2019·Nano-micro Letters·S Syama, P V Mohanan

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Methods Mentioned

BETA
Scanning Electron Microscopy
three hybrid

Software Mentioned

PeakFit
GraphPad Prism

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