Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.

Journal of Natural Products
Fan YangHou-Wen Lin

Abstract

Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureusin vitro.

References

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Citations

Feb 25, 2014·Applied Microbiology and Biotechnology·Randy Chi Fai CheungTzi Bun Ng
Apr 16, 2015·Applied Microbiology and Biotechnology·Tzi Bun NgAlaa El-Din Bekhit
Oct 19, 2013·Scientific Reports·Subhadeep GhoshDilip K Maiti
Feb 22, 2017·Chemistry & Biodiversity·Mei-Jun ChuGuo-Qiang Li
Nov 9, 2017·Marine Drugs·Huawei ZhangPhillip Crews
Jan 6, 2018·Marine Drugs·Pablo A GarcíaMaría-Ángeles Castro
Jan 7, 2014·Natural Product Reports·John W BluntMichèle R Prinsep
Feb 12, 2013·Natural Product Reports·Franz BucarMartin Schmid
May 7, 2013·Natural Product Reports·Zhong Jin
Dec 18, 2019·Pharmaceuticals·Mohammed AldholmiA Ganesan
Apr 30, 2015·Journal of Natural Products·Mario F C SantosRoberto G S Berlinck

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