Antimicrobial molecules in the lung: formulation challenges and future directions for innovation

Future Medicinal Chemistry
Arcadia Woods, Khondaker Miraz Rahman

Abstract

Inhaled antimicrobials have been extremely beneficial in treating respiratory infections, particularly chronic infections in a lung with cystic fibrosis. The pulmonary delivery of antibiotics has been demonstrated to improve treatment efficacy, reduce systemic side effects and, critically, reduce drug exposure to commensal bacteria compared with systemic administration, reducing selective pressure for antimicrobial resistance. This review will explore the specific challenges of pulmonary delivery of a number of differing antimicrobial molecules, and the formulation and technological approaches that have been used to overcome these difficulties. It will also explore the future challenges being faced in the development of inhaled products and respiratory infection treatment, and identify future directions of innovation, with a particular focus on respiratory infections caused by multiple drug-resistant pathogens.

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Citations

Sep 7, 2018·Breathe·Martyn F Biddiscombe, Omar S Usmani
Apr 18, 2019·Future Medicinal Chemistry·Rajesh PradhanKamal Dua
Jan 19, 2019·Annals of the American Thoracic Society·Dave P NicholsNicole Mayer-Hamblett
Jan 25, 2020·Nanomaterials·Jorge F Pontes, Ana Grenha
May 6, 2020·Pharmaceuticals·Natallia V Dubashynskaya, Yury A Skorik
Apr 6, 2021·International Journal of Nanomedicine·Alanood S AlmurshediAmany Z Mohamoud

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Clinical Trials Mentioned

NCT01315678
NCT01313624
NCT01314716

Software Mentioned

Arikace
PulmoSphere

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