Antimicrobial Monomers for Polymeric Dental Restoratives: Cytotoxicity and Physicochemical Properties

Journal of Functional Biomaterials
Diane R BienekDrago Skrtic

Abstract

A trend for the next generation of polymeric dental restoratives is to incorporate multifunctional capabilities to regulate microbial growth and remineralize tooth surfaces. Polymerizable 2-(methacryloyloxy)-N-(2-(methacryloyloxy)ethyl)-N,N-dimethylethan-1-aminium bromide (IDMA1) andN,N'-([1,1'-biphenyl]-2,2'-diylbis(methylene))bis(2-(methacryloyloxy)-N,N-dimethylethan-1-aminium) bromide (IDMA2), intended for utilization in bi-functional antimicrobial and remineralizing composites, were synthesized, purified with an ethanol-diethyl ether-hexane solvent system, and validated by nuclear magnetic resonance (¹H and13C NMR) spectroscopy, mass spectrometry, and Fourier-transform infrared spectroscopy. When incorporated into light-curable urethane dimethacrylate (UDMA)/polyethylene glycol-extended UDMA (PEG-U)/ethyl 2-(hydroxymethyl)acrylate (EHMA) (assigned UPE) resins, IDMAs did not affect the overall resins' hydrophilicity/hydrophobicity balance (water contact angle: 60.8-65.5°). The attained degrees of vinyl conversion (DVC) were consistently higher in both IDMA-containing copolymers and their amorphous calcium phosphate (ACP) composites (up to 5% and 20%, respectively) reaching 92.5% in IDMA2 formulations. Notably, these high DVC...Continue Reading

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Citations

Aug 6, 2020·Journal of Functional Biomaterials·Leopoldo Torres, Diane R Bienek
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ugochukwu C OkekeStanislav A Frukhtbeyn
Jan 12, 2021·Biomedical Microdevices·Khanh L LyXiaolong Luo

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Methods Mentioned

BETA
nuclear magnetic resonance
X-ray
Assay
atomic emission spectroscopy

Software Mentioned

DeltaGraph6
Excel2016
Testworks4
Systat
Chemist Application

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