Antimicrobial nanofibrous mats with controllable drug release produced from hydrophobized hyaluronan.

Carbohydrate Polymers
Lenka BardoňováVladimír Velebný

Abstract

Due to their large active surface, high loading efficiency, and tunable dissolution profiles, nanofibrous mats are often cited as promising drug carriers or antimicrobial membranes. Hyaluronic acid has outstanding biocompatibility, but it is hydrophilic. Nanofibrous structures made from hyaluronan dissolve immediately, making them unsuitable for controlled drug release and longer applications. We aimed to prepare a hyaluronan-based antimicrobial nanofibrous material, which would retain its integrity in aqueous environments. Self-supporting nanofibrous mats containing octenidine dihydrochloride or triclosan were produced by electrospinning from hydrophobized hyaluronan modified with a symmetric lauric acid anhydride. The nanofibrous mats required no cross-linking to be stable in PBS for 7 days. The encapsulation efficiency of antiseptics was nearly 100%. Minimal release of octenidine was observed, while up to 30% of triclosan was gradually released in 72 h. The nanofibrous materials exhibited antimicrobial activity, the fibroblast viability was directly dependent on the antiseptic content and its release.

References

Jul 1, 1997·Journal of Internal Medicine·J R FraserU B Laurent
Mar 22, 2001·Advanced Drug Delivery Reviews·T ArakawaJ F Carpenter
Oct 22, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Geert VerreckMarcus E Brewster
Jul 13, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kwangsok KimMichael Hadjiargyrou
Nov 5, 2005·Nucleic Acids Research·Dehai LiangBenjamin Chu
Mar 25, 2006·Biomaterials·Yuan JiMiriam H Rafailovich
Mar 28, 2008·The Journal of Antimicrobial Chemotherapy·Gerald Müller, Axel Kramer
May 21, 2010·Skin Pharmacology and Physiology·N-O HübnerA Kramer
Aug 16, 2012·International Wound Journal·Joseph S Frenkel
Dec 24, 2013·Acta Biomaterialia·Kevin T DickerXinqiao Jia
Jul 20, 2014·Carbohydrate Polymers·Gloria Huerta-AngelesVladimír Velebný
Sep 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shih-Feng ChouKim A Woodrow
Oct 9, 2015·International Journal of Cell Biology·Jaime M CyphertStavros Garantziotis
Oct 27, 2015·BMB Reports·Pyung-Hwan Kim, Je-Yoel Cho
Oct 31, 2016·International Journal of Biological Macromolecules·Vojtech ZapotockyVladimir Velebny
Dec 19, 2016·International Journal of Pharmaceutics·Ivan J Hall BarrientosDimitrios A Lamprou
Aug 16, 2017·International Journal of Pharmaceutics·Ivan J Hall BarrientosDimitrios A Lamprou
May 11, 2018·Colloids and Surfaces. B, Biointerfaces·Sónia P MiguelIlídio J Correia
Mar 12, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sónia P MiguelIlídio J Correia
Sep 2, 2019·Carbohydrate Polymers·Josef ChmelařVladimír Velebný
Nov 16, 2019·International Journal of Biological Macromolecules·Xiao ChenYingshan Zhou
Mar 13, 2020·Biomaterials Research·Saba KhoshbakhtYaeghob Sharifi
Nov 1, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anabela MoreiraGareth R Williams
Dec 31, 2020·Pharmaceutics·Alma Akhmetova, Andrea Heinz
Mar 7, 2021·Carbohydrate Polymers·Fuxin XueYichun Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.