Antimicrobial options in the treatment of adult staphylococcal bone and joint infections in an era of drug shortages

Orthopedics
Allison L Mruk, Kenneth E Record

Abstract

Staphylococcus aureus is the most pathogenic bacterium and the most common cause of osteomyelitis, affecting 50% to 70% of cases. Many antistaphylococcal agents with varying activity against methicillin-susceptible S aureus and methicillin-resistant S aureus are available in the US market. This article reviews the most common antistaphylococcal agents used in the treatment of bone and joint infections in adult patients and focuses on the antimicrobial agent's mechanism of action, US Food and Drug Administration-approved indications, place in therapy, monitoring parameters, and common side effects.

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Citations

May 28, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Vuk UskokovićTejal A Desai
Mar 8, 2014·Clinics in Orthopedic Surgery·Laura Prieto-PérezJaime Esteban
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Jun 12, 2018·Frontiers in Microbiology·Peisheng ChenBin Yu
Feb 5, 2021·The Annals of Pharmacotherapy·Timothy W JonesWilliam J Olney

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