PMID: 7023900May 1, 1981Paper

Antimicrobial penetration into cerebrospinal fluid

Drug Intelligence & Clinical Pharmacy
M L RichardsJ L LeFrock

Abstract

The complex physiology of the blood-brain barrier and the characteristics of an antimicrobial which govern its distribution into the brain are poorly understood. Likewise, available data regarding CSF antimicrobial concentrations after extra-CNS administration, as tabulated in this review, are inadequate. Because of the potentially dire consequences that result from inappropriately treated CNS infections, large cooperative studies using standardized methodology are needed. Suggestions for such methods are outlined.

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Citations

Jul 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·K Chan, C L Wong
Dec 1, 1984·Drug Intelligence & Clinical Pharmacy·R E PolkP Patterson
Apr 30, 1998·The Annals of Pharmacotherapy·C L ShafferP Gal
Dec 1, 1984·European Journal of Clinical Microbiology·W M Scheld
Jan 1, 1992·The Annals of Pharmacotherapy·R W BarronsR M Richey
Oct 1, 1986·European Journal of Clinical Microbiology·U B Schaad
Feb 1, 1991·Journal of Clinical Pharmacy and Therapeutics·A WaluboC L Wong

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