Antimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseases

Oral Diseases
Oya TürkoğluGül Atilla

Abstract

To investigate the levels of antimicrobial peptide hCAP-18/LL-37 protein and mRNA expression in gingival tissues with different periodontal disease. Ten patients with generalized aggressive periodontitis, 10 patients with chronic periodontitis, and 10 healthy controls were included in this study. Periodontal parameters including probing depth, clinical attachment level, plaque index, and papilla bleeding index were assessed in study subjects. hCAP-18/LL-37 mRNA analysis by RT-PCR and immunohistochemistry were performed in 19 samples provided enough RNA in terms of concentration and integrity. This study demonstrated that hCAP-18/LL-37 was a product of neutrophils. Tissue samples of chronic periodontitis patients had significantly higher immunostaining of hCAP-18/LL-37 on neutrophils infiltrating in both epithelium and connective tissue compared with controls. hCAP-18/LL-37 mRNA expression levels in tissue samples of chronic periodontitis patients seemed to be upregulated compared with controls. While two generalized aggressive periodontitis patients showed downregulated hCAP-18/LL-37 mRNA expression levels, one generalized aggressive periodontitis patient showed slightly increased hCAP-18/LL-37 mRNA level compared with controls...Continue Reading

References

Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A WeinbergB A Dale
Mar 17, 2000·Immunological Reviews·H G Boman
Jun 23, 2000·Annals of Periodontology·G C Armitage
Oct 5, 2001·Journal of Periodontal Research·B A DaleA Weinberg
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·J M GuthmillerB F Tack
Nov 28, 2002·Journal of Dental Research·M MurakamiR L Gallo
Mar 1, 2003·Journal of Periodontal Research·Gustavo P GarletJoão S Silva
Apr 26, 2003·The Journal of Investigative Dermatology·Mohamed ZaiouRichard L Gallo
Jun 6, 2003·Cellular and Molecular Life Sciences : CMLS·R Bals, J M Wilson
Jul 1, 1962·The Journal of the American Dental Association·G A QUIGLEY, J W HEIN
Dec 6, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D F Kinane, T C Hart
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karsten GronertCharles N Serhan
Mar 9, 2004·Journal of Clinical Microbiology·Sophie JolyJanet M Guthmiller
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Alaina ArochoQiulu Pan
Jan 12, 2007·Periodontology 2000·Huanxin MengYibing Zhao
Feb 3, 2007·FEMS Immunology and Medical Microbiology·Robert P AllakerIan J McKay

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Citations

Aug 2, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F S MarianoR B Gonçalves
Aug 25, 2012·Future Medicinal Chemistry·Andreas S Jacobsen, Håvard Jenssen
Jun 21, 2014·BioMed Research International·Oya TürkoğluGül Atilla
Jun 20, 2013·Archives of Oral Biology·Sotiria DavidopoulouSotirios Kalfas
Aug 13, 2013·Periodontology 2000·Ara GreerRichard P Darveau
Nov 10, 2011·Journal of Periodontal Research·D Jönsson, B-O Nilsson
Apr 5, 2014·Journal of Periodontal Research·D SvenssonB-O Nilsson
Jun 21, 2015·Immunobiology·Dogukan YılmazUlvi Kahraman Gursoy
Jan 8, 2011·Archives of Oral Biology·Oya TürkoğluGül Atilla
Feb 18, 2012·Archives of Oral Biology·Sotiria DavidopoulouSotirios Kalfas
Jan 3, 2015·Archives of Oral Biology·Oya TürkoğluGül Atilla
May 1, 2016·Clinical Oral Investigations·Oya TurkogluGül Atilla
Sep 18, 2012·Journal of Dental Research·C SupanchartS Krisanaprakornkit
Mar 10, 2018·Journal of Periodontology·Zhanyi GaoHuanxin Meng
Jun 20, 2019·Journal of Periodontal Research·Marie-Laure JourdainJulien Braux
Aug 5, 2020·International Journal of Implant Dentistry·Oya TurkogluHarika Atmaca
Oct 28, 2020·Journal of Periodontology·Churen ZhangJianxia Hou

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