Antimicrobial peptides and peptidomimetics - potent therapeutic allies for staphylococcal infections

Current Pharmaceutical Design
Haroon MohammadMohamed N Seleem

Abstract

The pervasiveness of bacterial resistance to conventional antibiotics, particularly those associated with staphylococcal infections, has become a global epidemic. However, research involving antimicrobial peptides (AMPs) and their synthetic analogues has unearthed a potentially novel class of antibacterials for the treatment of an array of diseases caused by pathogenic bacteria, such as staphylococci. AMPs have several unique advantages over traditional antibiotics such as the projected slow emergence of bacterial resistance to these agents and their capability to modulate the host immune response to infection. Unfortunately, their susceptibility to proteolytic degradation, loss of antimicrobial activity due to serum binding or physiological concentration of salts, and toxicity to host tissues has limited their use as systemic agents thus far. Additionally, the presence of economic and regulatory obstacles has hindered the translation of AMPs, as antimicrobials, from the bench to the clinic. The present review delves further into the benefits and challenges of utilizing AMPs as antibacterial agents (particularly for staphylococcal infections), the methods which have been utilized to overcome their limitations, their successes a...Continue Reading

Citations

Jun 27, 2015·Scientific Reports·Shankar ThangamaniMohamed N Seleem
Nov 11, 2015·Scientific Reports·Shankar ThangamaniMohamed N Seleem
Mar 24, 2018·Future Medicinal Chemistry·Wooseong KimEleftherios Mylonakis
Sep 19, 2018·Drug Discoveries & Therapeutics·Siddhartha KumarAntresh Kumar
Oct 31, 2018·The Journal of Antimicrobial Chemotherapy·D P R TroemanJ A J W Kluytmans
May 12, 2016·Advanced Materials·Małgorzata A WronskaJ Gerard Wall
May 21, 2020·Surgical Infections·Christen E SalyerCharles C Caldwell
Oct 13, 2016·ChemMedChem·Chandradhish GhoshJayanta Haldar
Aug 24, 2019·Protein and Peptide Letters·Jaspreet Kaur Boparai, Pushpender Kumar Sharma

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