Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastrointestinal tracts

Cell and Tissue Research
Jenny WahRobert Bals

Abstract

Previous studies have implicated antimicrobial peptides in the host defense of the mammalian intestinal and respiratory tract. The aim of the present study has been to characterize further the expression of these molecules in non-epithelial cells of the human pulmonary and digestive systems by detailed immunohistochemical analysis of the small and large bowel and of the large airways and lung parenchyma. Additionally, cells obtained from bronchoalveolar lavage were analyzed by fluorescent activated cell sorting and immunostaining of cytospin preparations. hBD-1, hBD-2, and LL-37 were detected in lymphocytes and macrophages in the large airways, lung parenchyma, duodenum, and colon. Lymphocytes positive for the peptides revealed a staining pattern and distribution that largely matched that of CD3-positive and CD8-positive T-cells. Macrophages with positive staining for the antimicrobial peptides also stained positively for CD68 and CD74. In view of the morphology of the LL-37-positive and hBD-2-positive mucosal lymphocytes, they are probably also B-cells. Thus, antimicrobial peptides of the defensin and cathelicidin families are present in a variety of non-epithelial cells of mucosal organs. These findings confirm that antimicro...Continue Reading

References

Jan 25, 1991·Cell·R I LehrerM E Selsted
Jul 1, 1990·Journal of Periodontal Research·T H HowellR C Williams
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·B AgerberthG H Gudmundsson
Jan 1, 1995·Annual Review of Immunology·H G Boman
Apr 1, 1995·Infection and Immunity·J W LarrickS C Wright
Mar 1, 1997·American Journal of Respiratory Cell and Molecular Biology·P B McCray, L Bentley
Jun 26, 1997·Nature·J HarderJ M Schröder
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·W I LencerJ L Madara
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R BalsJ M Wilson
Sep 3, 1998·The Journal of Clinical Investigation·R BalsJ M Wilson
Dec 26, 2001·Current Opinion in Hematology·Robert I Lehrer, Tomas Ganz
Jan 25, 2002·Nature·Michael Zasloff
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian C SchuttePaul B McCray
May 16, 2002·Infection and Immunity·Christian MoserJames M Wilson
Feb 1, 2003·Drugs·Andreas R Koczulla, Robert Bals
Jun 5, 2003·The Journal of Clinical Investigation·Rembert KoczullaRobert Bals
Jun 6, 2003·Cellular and Molecular Life Sciences : CMLS·R Bals, J M Wilson

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Citations

Jan 6, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Robert BuckiWojciech Sokołowski
Mar 4, 2008·Journal of Veterinary Internal Medicine·A LindeT Melgarejo
May 3, 2008·Biochemical and Biophysical Research Communications·Suhua HanMonique L van Hoek
Apr 9, 2008·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Mechthild StoeckelhuberRobert Bals
Jul 21, 2011·European Journal of Immunology·Nicholas W KinJohn F Kearney
Mar 3, 2009·Journal of the American Academy of Dermatology·Christoph SchlapbachRobert E Hunger
Apr 28, 2016·Pharmacological Reports : PR·Adam FabisiakJakub Fichna
Feb 26, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Malcolm B LowryAdrian F Gombart
Sep 24, 2013·Acta Oto-laryngologica·Camilla Rydberg MillrudLars Olaf Cardell
Mar 27, 2012·FEMS Immunology and Medical Microbiology·Jesper BogeforsLars-Olaf Cardell
Mar 17, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Sarah DimeloeCatherine Hawrylowicz
Feb 18, 2012·Archives of Oral Biology·Sotiria DavidopoulouSotirios Kalfas
Jul 16, 2008·FEMS Immunology and Medical Microbiology·Malin BrybornMikael Adner
Jul 21, 2009·Biochemical Society Transactions·Tracy Hussell, Mary M Cavanagh
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian R MartineauRobert J Wilkinson
Apr 3, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M Bauer, R Wetzker
Aug 5, 2010·Nuclear Medicine Communications·Jesús Sepúlveda-MéndezMartha Pedraza-López
Aug 1, 2007·Placenta·A E KingJ R G Challis

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