Antimicrobial peptides from the venoms of Vespa bicolor Fabricius

Peptides
Wenhu ChenHaining Yu

Abstract

Hornets possess highly toxic venoms, which are rich in toxins, enzymes and biologically active peptides. Many bioactive substances have been identified from wasp venoms. Vespa mastoparan (MP-VBs) and Vespa chemotatic peptide presenting antimicrobial action (VESP-VBs) were purified and characterized from the venom of the wasp, Vespa bicolor Fabricius. The precursors encoding VESP-VBs and MP-VBs were cloned from the cDNA library of the venomous glands. Analyzed by FAB-MS, the amino acid sequence and molecular mass for VESP-VB1 were FMPIIGRLMSGSL and 1420.6, for MP-VB1 were INMKASAAVAKKLL and 1456.5, respectively. The primary structures of these peptides are homologous to those of chemotactic peptides and mastoparans isolated from other vespid venoms. These peptides showed strong antimicrobial activities against bacteria and fungi and induced mast cell degranulation, but displayed almost no hemolytic activity towards human blood red cells.

References

Aug 1, 1979·Chemical & Pharmaceutical Bulletin·Y HiraiC Kitada
Sep 1, 1977·Chemical & Pharmaceutical Bulletin·T Nakajima, T Yasuhara
Jul 28, 1972·Science·E Habermann
Jun 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·G S Bignami
Jun 27, 1998·Toxicon : Official Journal of the International Society on Toxinology·C L HoY L Lin
Apr 3, 1999·Cellular and Molecular Life Sciences : CMLS·C HöllerC Nanoff
Dec 22, 1999·Current Opinion in Chemical Biology·D G McCaffertyR Kruger
Jan 25, 2002·Nature·Michael Zasloff
Jul 1, 2004·Toxicon : Official Journal of the International Society on Toxinology·Maria Anita MendesMario Sergio Palma
Aug 20, 2004·The Journal of Peptide Research : Official Journal of the American Peptide Society·M P dos Santos CabreraJ Ruggiero Neto
Dec 8, 2004·Toxicon : Official Journal of the International Society on Toxinology·Maria Anita MendesMario Sergio Palma
Dec 7, 2005·Toxicon : Official Journal of the International Society on Toxinology·Xueqing XuRen Lai
Jul 11, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yuko OgawaRyohei Yanoshita
Jul 28, 2006·Biochemical and Biophysical Research Communications·Zuohong ZhouRen Lai
Oct 19, 2006·Peptides·Xueqing XuRen Lai
Jun 19, 2007·Toxicon : Official Journal of the International Society on Toxinology·Haining YuJingze Liu
Nov 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·Hailong YangRen Lai
Mar 1, 2008·Toxicon : Official Journal of the International Society on Toxinology·Junyou HanQingxiong Meng

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Citations

Apr 11, 2014·Journal of Natural Products·Alvaro SianoGeorgina G Tonarelli
May 2, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Deepak Kumar KaushikAnirban Basu
Aug 5, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Paula G CzaikoskiMarta C Monteiro
Mar 5, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Xinbo YangHaining Yu
Sep 10, 2013·Toxicon : Official Journal of the International Society on Toxinology·Xinwang YangYun Zhang
Nov 29, 2011·Toxicon : Official Journal of the International Society on Toxinology·Márcia Renata MortariElisabeth Ferroni Schwartz
Jul 24, 2020·Archives of Toxicology·Cayetano HerreraEmma Martínez-López
Jun 24, 2018·Pharmaceutics·Ilaria PassariniMire Zloh
Sep 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Seema Patel, Nadeem Akhtar
Apr 15, 2018·Toxicon : Official Journal of the International Society on Toxinology·Rose OmbatiRen Lai
Jun 16, 2021·Toxicon : Official Journal of the International Society on Toxinology·Yi-Chuan MengKen Tan

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