Antimicrobial Peptides in Innate Immunity against Mycobacteria

Immune Network
Dong-Min Shin, Eun-Kyeong Jo

Abstract

Antimicrobial peptides/proteins are ancient and naturallyoccurring antibiotics in innate immune responses in a variety of organisms. Additionally, these peptides have been recognized as important signaling molecules in regulation of both innate and adaptive immunity. During mycobacterial infection, antimicrobial peptides including cathelicidin, defensin, and hepcidin have antimicrobial activities against mycobacteria, making them promising candidates for future drug development. Additionally, antimicrobial peptides act as immunomodulators in infectious and inflammatory conditions. Multiple crucial functions of cathelicidins in antimycobacterial immune defense have been characterized not only in terms of direct killing of mycobacteria but also as innate immune regulators, i.e., in secretion of cytokines and chemokines, and mediating autophagy activation. Defensin families are also important during mycobacterial infection and contribute to antimycobacterial defense and inhibition of mycobacterial growth both in vitro and in vivo. Hepcidin, although its role in mycobacterial infection has not yet been characterized, exerts antimycobacterial effects in activated macrophages. The present review focuses on recent efforts to elucidate...Continue Reading

References

Jan 1, 1993·Annual Review of Immunology·Robert I LehrerTomas Ganz
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Robert BalsJ M Wilson
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·Birgitta AgerberthG H Gudmundsson
Jun 6, 2000·American Journal of Respiratory Cell and Molecular Biology·J HarderJ M Schröder
Jul 7, 2000·The Journal of Biological Chemistry·M N BeckerS H Randell
Jun 13, 2001·Infection and Immunity·J L Flynn, J Chan
Dec 26, 2001·Current Opinion in Hematology·Robert I Lehrer, Tomas Ganz
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian C SchuttePaul B McCray
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei WangRobert I Lehrer
Sep 10, 2003·Journal of Leukocyte Biology·Margherita Zanetti
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Alexander M Cole, Alan J Waring
Sep 21, 2004·The Journal of Infectious Diseases·Anjana KalitaG K Khuller
Nov 17, 2004·Current Protein & Peptide Science·Alexander M ColeRobert I Lehrer
Nov 30, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chunfu YangRenu B Lal
Mar 22, 2005·Immunologic Research·R J Fahy, M D Wewers
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kahori KurosakaDe Yang
Jun 25, 2005·Current Protein & Peptide Science·Christoph Beisswenger, Robert Bals
Oct 11, 2005·Biotechnology Letters·Kris De Smet, Roland Contreras
Aug 10, 2006·The Journal of Infectious Diseases·B Rivas-SantiagoRogelio Hernandez-Pando
Aug 17, 2006·Current Topics in Microbiology and Immunology·Tomas Ganz
Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mohamed Zaiou
Feb 24, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marc JacobsenStefan H E Kaufmann
Jul 4, 2007·The Journal of Clinical Investigation·Adrian R MartineauRobert J Wilkinson
Jul 5, 2007·Journal of Leukocyte Biology·Fatoumata B SowWilliam P Lafuse
Oct 27, 2007·Investigative Ophthalmology & Visual Science·Curtis R BrandtRobert I Lehrer
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Ylva Kai-Larsen, Birgitta Agerberth
Jun 11, 2008·Cell Host & Microbe·Jean Pieters
Jul 8, 2008·Current Opinion in Immunology·Philip T Liu, Robert L Modlin
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sif HansdottirGary W Hunninghake
Feb 17, 2009·Trends in Immunology·Yuping Lai, Richard L Gallo
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chul-Su YangEun-Kyeong Jo
Sep 15, 2009·Cell Host & Microbe·Jae-Min YukEun-Kyeong Jo
Sep 30, 2009·Seminars in Hematology·Tomas Ganz, Elizabeta Nemeth
Nov 13, 2009·Acta Haematologica·Elizabeta Nemeth, Tomas Ganz
Jan 23, 2010·Biologicals : Journal of the International Association of Biological Standardization·WHO
Jun 19, 2010·Cellular Microbiology·Eun-Kyeong Jo
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kristina EdfeldtRobert L Modlin
Jan 18, 2011·Clinical and Experimental Immunology·C E Rivas-SantiagoR Hernández Pando

Citations

May 20, 2014·Journal of Medical Microbiology·Nima MotamediLuiz E Bermudez
Apr 27, 2013·Pathogens and Disease·Eun-Kyeong Jo
Jan 1, 2013·Pathogens·Jorge I Castañeda-SánchezJulieta Luna-Herrera
Jul 26, 2018·Biomarkers in Medicine·Mariana Salgado-BustamanteYamilé López-Hernández
May 30, 2013·Antimicrobial Agents and Chemotherapy·David PulidoEster Boix
Aug 20, 2019·Chinese Medical Journal·Jing ZhangYan Rao
Jul 18, 2020·Nutrition Reviews·Fatemeh Hadizadeh
Aug 7, 2019·Journal of Clinical Medicine·Yash DaraVishwanath Venketaraman
Sep 6, 2020·Antibiotics·Marta Filipa SimõesAndré Antunes
Mar 7, 2017·Frontiers in Neuroscience·Jianguo LiRoger W Beuerman
Nov 23, 2017·Frontiers in Immunology·Javier Arranz-TrullénEster Boix
Feb 18, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rui YangZheng W Chen
Nov 27, 2018·The Journal of Veterinary Medical Science·Afia KhatunMasahiro Morimoto
Jan 7, 2021·Photodermatology, Photoimmunology & Photomedicine·Faiza SajjadZhi-Long Chen
Nov 5, 2020·Nutrients·Joseph MercolaCarol L Wagner

Related Concepts

Antibiotics
Autophagy
Macrophage
Genus Mycobacterium
Mycobacterium Infections
Peptides
Defensins
Cytokine
Chemokine
Immune Response

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