Antimicrobial peptides: mediators of innate immunity as templates for the development of novel anti-infective and immune therapeutics

Current Pharmaceutical Design
P S HiemstraJ M Sallenave

Abstract

Antimicrobial molecules are ancient and essential small cationic molecules of the host defence system which are found in a wide variety of species. They display antimicrobial activity against a wide range of bacteria, fungi and viruses, an activity that has been mostly attributed to the disruption of microbial membranes. In this article, we will review the "classical" functions of 3 classes of antimicrobial molecules, namely defensins, cathelicidins, and the four-disulfide core proteins secretory leukocyte proteinase inhibitor (SLPI) and elafin. In addition to the study of their expression in a variety of cell types and the regulation of their production, we will also describe novel properties of these molecules that have been highlighted by recent studies. These include their ability to chemoattract a variety of inflammatory, immune and other cell types (neutrophils, macrophages, monocytes, lymphocytes, mast cells, epithelial cells) in vitro and in vivo. In addition, we will discuss the potential use of these newly discovered properties for therapeutic or vaccination purposes, using protein- or gene-transfer based methodologies. Finally, we will examine in an extensive fashion the strategies used by microorganisms to circumven...Continue Reading

Citations

Sep 9, 2006·Epidemiology and Infection·J J CannellE Giovannucci
Dec 15, 2005·The Journal of Experimental Medicine·Clifford C TaggartNoel G McElvaney
Jul 28, 2009·QJM : Monthly Journal of the Association of Physicians·D ScottG Jones
Nov 26, 2009·AIDS·Daniel Malamud, Sharon M Wahl
Jan 18, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon M WahlUNKNOWN DATRI 009 Study Group
Jan 16, 2007·Antimicrobial Agents and Chemotherapy·Andrea GiacomettiGiorgio Scalise
Jan 21, 2006·American Journal of Respiratory Cell and Molecular Biology·Ali RoghanianJean-Michel Sallenave
Mar 2, 2011·Journal of Inflammation·Venkata J AdapalaKolapo M Ajuwon
Oct 30, 2009·International Journal of Molecular Sciences·Lars SteinstraesserSammy Al-Benna
Aug 28, 2010·Medical Mycology·Antonella LupettiPeter H Nibbering
Jul 25, 2006·Expert Opinion on Investigational Drugs·Jamie S Mader, David W Hoskin
May 5, 2011·Peptides·Jack Ho WongDavid Chi Cheong Wan
Aug 5, 2008·Trends in Immunology·Colin D Bingle, Annapurna Vyakarnam
Dec 13, 2005·Current Opinion in Immunology·Kelly L Brown, Robert E W Hancock
Nov 15, 2008·Expert Opinion on Therapeutic Targets·Catherine M GreeneNoel G McElvaney
Nov 30, 2010·Molecular Immunology·Aram B VrolingGeorg Kraal
Jun 1, 2014·The Lancet Infectious Diseases·Tobias StrunkOfer Levy
Aug 29, 2014·Expert Review of Proteomics·Moo-Jin SuhRembert Pieper
May 26, 2006·Scottish Medical Journal·M A GibbonsA J Simpson
Feb 13, 2009·European Journal of Gastroenterology & Hepatology·Thomas WexPeter Malfertheiner
Aug 2, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Laszlo Otvos
Feb 8, 2006·European Journal of Gastroenterology & Hepatology·Istvan HritzPeter Malfertheiner
Sep 20, 2007·The Journal of Biological Chemistry·Patrick GeraghtyNoel G McElvaney
Dec 25, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ricardo A ChaurioUdo S Gaipl
May 20, 2020·Frontiers in Physiology·Alexis CatalaAngelo D'Alessandro
May 24, 2013·International Journal of Molecular Sciences·Anna BogdanovaLars Kaestner
Mar 1, 2008·Proteomics. Clinical Applications·Jens Rauch, Olivier Gires
Feb 24, 2015·Frontiers in Immunology·Peter J SpäthIsabella Quinti
Aug 30, 2016·Cell Biology International·Anna StachurskaJadwiga Fabijańska-Mitek
Feb 18, 2017·Frontiers in Immunology·Thomas R L KleiRobin van Bruggen
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janneke N SamsomGeorg Kraal
Dec 13, 2005·Clinical Science·Steven E WilliamsJean-Michel Sallenave

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Leukocyte Biology
Dawn M E BowdishRobert E W Hancock
Nature Reviews. Microbiology
B Brett Finlay, Robert E W Hancock
© 2021 Meta ULC. All rights reserved